Compare Rowasa vs. Sulfasalazine

Rowasa (mesalamine) and Azulfidine (sulfasalazine) are both used to treat ulcerative colitis (UC), but they have some key differences. Rowasa is an enema that you insert rectally, while Azulfidine is an oral tablet. Rowasa works directly in your colon to reduce inflammation, but it can cause discomfort during use and has a risk of allergic reactions, especially if you're sensitive to sulfites. Azulfidine, on the other hand, is also used to treat rheumatoid arthritis (RA) and can be taken by children 6 years and older. It breaks down in your body into chemicals that help reduce inflammation, but it can cause stomach issues like nausea and vomiting. Both medications are available as lower-cost generics, but Azulfidine might require regular blood tests to monitor your liver, kidneys, and blood counts. Additionally, Azulfidine can lower sperm count, which is reversible after stopping the medication.