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Stribild vs. Edurant

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Stribild (elvitegravir/cobicistat/emtricitabine/tenofovir disoproxil fumarate) and Edurant (rilpivirine) are both medications used to treat HIV. However, they belong to different classes of antiretrovirals. Stribild is a combination medication that includes an integrase inhibitor and two nucleoside reverse transcriptase inhibitors (NRTIs), while Edurant is a non-nucleoside reverse transcriptase inhibitor (NNRTI). Both medications are taken once daily with food, but Edurant must be combined with other HIV medications. Stribild is not recommended for people with kidney or liver problems, while Edurant can be used in those with mild-to-moderate kidney and liver problems. Stribild can cause nausea and diarrhea and should not be taken within 2 hours of antacids. Edurant can cause depression and liver problems and should not be taken with certain heartburn medications like omeprazole. Additionally, Stribild is not recommended during pregnancy, while Edurant is considered safe for use during pregnancy.

Stribild

 

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Edurant

(rilpivirine)

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Summary for Stribild

Prescription only

Stribild is a single-tablet-regimen containing 3 HIV antiretrovirals (ARVs), elvitegravir (Vitekta), emtricitabine (Emtriva), and tenofovir DF (Viread), and one booster medication, cobicistat (Tybost).

Indications for Stribild

  • HIV treatment

Pros and Cons for Stribild

Pros

  • 1 tablet once a day is a full HIV regimen
  • Contains tenofovir, which is also a first-choice treatment option for hepatitis B
  • One of the few single-tablet-regimens that contains an integrase inhibitor (a preferred HIV ARV subclass)
  • In clinical trials, caused less abnormal dreams than Atripla
  • Gilead copay card available for people with commercial health plans (not for use with Medicaid and Medicare plans)

Cons

  • Must be taken with food
  • Dose can't be adjusted, so it's not recommended for people with kidney or liver problems
  • Can cause kidney and bone problems
  • Interacts with a lot of medications
  • Not a good option for people who are pregnant, or plan to become pregnant

Common Side Effects for Stribild

  • Nausea (16%)
  • Diarrhea (12%)
  • Abnormal, strange dreams (9%)
  • Headache (7%)

Warnings for Stribild

  • WORSENING OF HEPATITIS B
  • CHANGES IN KIDNEY FUNCTION
  • LIVER PROBLEMS
  • DRUG INTERACTIONS
  • BONE PROBLEMS
  • IMMUNE RECONSTITUTION SYNDROME

Summary for Edurant

Prescription only

Edurant (rilpivirine) is a once-daily antiretroviral medication that's taken by mouth and is used to treat human immunodeficiency virus (HIV) infection. It's approved for use in adults and children. Edurant (rilpivirine) is taken with other antiretroviral medications when it's used for certain people who've never had HIV treatment before. Edurant (rilpivirine) can also be used for a short period of time before starting Cabenuva (cabotegravir / rilpivirine). Side effects of Edurant (rilpivirine) can include depression, headache, and trouble sleeping.

Indications for Edurant

  • Treatment of HIV-1 infection in people 2 years and older, weighing at least 30 pounds, with an HIV viral load of less than 100,000 copies/mL and who haven't taken HIV medications before
  • Short-term treatment of HIV-1 infection in certain people ages 12 years and older, weighing at least 77 pounds, who are planning to start or planning to miss a dose of Cabenuva (cabotegravir / rilpivirine)

Pros and Cons for Edurant

Pros

  • Taken by mouth once a day, so it's convenient for people with a busy schedule
  • Can use in people with mild-to-moderate kidney and liver problems
  • Safe to use during pregnancy

Cons

  • Can cause some allergic skin reactions
  • Must take with a meal
  • Only available as a brand-name medication

Common Side Effects for Edurant

Warnings for Edurant

  • Severe skin reactions and allergic reactions
  • Liver problems
  • Depression and suicidal thoughts
  • Overactive immune system
  • Interaction with other medications

Prices with our coupons for Stribild vs. Edurant

Price Card Drug Icon
Stribild30 tablets / 150mg/150mg/200mg/300mg
$4,460.07$5,696.14
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Price Card Drug Icon
Rilpivirine30 tablets / 25mg of
$408.82$1,272.11
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