Key takeaways
Zaleplon (Sonata) and ramelteon (Rozerem) are both medications used to treat insomnia, but they work in different ways and have distinct characteristics. Zaleplon is a sedative-hypnotic that works on gamma-aminobutyric acid (GABA) receptors to help you fall asleep quickly, but it is a controlled substance and can be habit-forming. It is typically used for short-term treatment and may cause withdrawal symptoms if stopped abruptly. On the other hand, ramelteon is a melatonin receptor agonist that mimics the natural hormone melatonin to regulate your sleep cycle. It is not a controlled substance and is not known to be habit-forming. Ramelteon has fewer side effects and is available as a generic medication, but it should not be taken with or right after a high-fat meal. While both medications can cause drowsiness and dizziness, zaleplon has a higher risk of causing unusual behaviors like sleep-walking and sleep-driving.
