Plavix vs. Ticlid for Stroke Risk Reduction: Important Differences and Potential Risks.

Key takeaways

Clopidogrel (Plavix) and ticlopidine (Ticlid) are both antiplatelet medications used to prevent blood clots. They work by stopping platelets in your blood from clumping together. However, there are several differences between the two. Ticlopidine has been discontinued in the United States and is no longer available. Clopidogrel is taken once daily, typically at a dose of 75 mg, and is used for preventing heart attacks, strokes, and in people with peripheral artery disease. Clopidogrel can cause side effects like bleeding and bruising, and it interacts with many medications, such as certain antidepressants and NSAIDs. Ticlopidine was discontinued partly due to its risk of serious blood problems, and safer alternatives such as clopidogrel are now preferred.

Clopidogrel

(Plavix)

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Ticlopidine

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Summary for Plavix

Prescription only

Clopidogrel (Plavix) is a prescription antiplatelet medication that helps lower your risk of heart attack or stroke. It works by stopping platelets in your blood from sticking together and forming clots. You take it as a tablet by mouth once a day, and it might be used alone or with aspirin in some situations. Since it's a blood thinner, the most common side effect is bleeding.

Indications for Plavix

Lower the risk of heart attack or stroke in people with acute coronary syndrome (ACS)
Lower the risk of heart attack or stroke in people who recently had one, or who have peripheral artery disease

Pros and Cons for Plavix

Pros

Good choice for lowering the risk of heart attack or stroke
Tablet that's taken once a day by mouth
Can be taken with or without food

Cons

Can cause major bleeding or bruising
Has many interactions with other medications
Might not work as well for people with East Asian descent

Common Side Effects for Plavix

Minor bleeding (5%)
Major bleeding (4%)

Warnings for Plavix

Clopidogrel (Plavix) not working as well
Bleeding
Risk of heart attack or stroke if stopped suddenly
Blood clotting condition
Allergic reaction

Summary for Ticlid

Discontinued

Ticlopidine is used to lower the risk of stroke in certain people. It's also used to prevent blood clotting in people who have had coronary stent implantation. This medication was discontinued and is no longer available in the United States.