Key takeaways
Odefsey (emtricitabine/rilpivirine/tenofovir alafenamide) and Edurant (rilpivirine) are both medications used to treat HIV, but they have some key differences. Odefsey is a combination of three antiretrovirals, including rilpivirine, and is taken as a single tablet once a day with a meal. It is designed to be a complete HIV treatment regimen on its own. In contrast, Edurant contains only rilpivirine and must be taken with other antiretroviral medications. Edurant is also used for short-term treatment before starting Cabenuva injections. Odefsey is noted for being safer for your kidneys and bones compared to older treatments, while Edurant is highlighted for its convenience and safety in people with mild-to-moderate kidney and liver problems. Both medications must be taken with a meal and have similar side effects, such as depression and liver issues. However, Odefsey has additional risks like bone density loss and kidney problems, which are not mentioned for Edurant.
