Key takeaways
Methyltestosterone (Methitest) and testosterone gel (Testim, AndroGel, Fortesta, Vogelxo) are both medications used for testosterone replacement therapy in males with low testosterone levels. They belong to the same drug class and are controlled substances due to their potential for misuse and dependency. However, they differ in several ways. Methyltestosterone is an oral medication available in tablet or capsule form, while testosterone gel is applied topically to the skin. Methyltestosterone is also FDA-approved for treating delayed puberty in males and breast cancer in females, whereas testosterone gel is only approved for low testosterone in males. Both medications are available as a lower-cost generic. Common side effects of methyltestosterone include acne and headaches, while testosterone gel can cause skin irritation, acne, and rash. Both medications can interact with blood thinners, but because testosterone gel is applied topically there is a risk of transferring the medication to someone else through skin-to-skin contact.
