Key takeaways
Meclizine (Antivert, Dramamine Less Drowsy) and ondansetron (Zofran) are both used to treat nausea and vomiting, but they belong to different medication classes. Meclizine is an antihistamine, while ondansetron is an antiemetic. Meclizine is available over-the-counter for motion sickness and by prescription for vertigo, whereas ondansetron is prescription-only and used to prevent nausea and vomiting after surgery or cancer treatments. Meclizine comes in chewable tablets or pills, while ondansetron is available as tablets, orally disintegrating tablets, and liquid, and can also be given as an injection by a healthcare professional. Meclizine can cause sleepiness, dry mouth, and difficulty urinating, while ondansetron may lead to headaches, tiredness, and constipation or diarrhea. Ondansetron can interact with medications like antidepressants and migraine medications, while meclizine can interact with anticholinergic medications. Both medications are available as a lower-cost generic.
