Key takeaways
Sustol ER (granisetron) and Emend (aprepitant) are both medications used to prevent nausea and vomiting caused by chemotherapy, but they have some key differences. Sustol ER is an antiemetic that works by blocking serotonin in the brain and is given as an injection under the skin by a healthcare professional. It lasts up to 7 days and is not approved for use in children. On the other hand, Emend is an NK1 receptor antagonist that blocks different chemicals in the brain and is taken orally. Emend is available in both capsule and oral solution forms, making it suitable for children as young as 6 months old. Sustol ER is typically given once every 7 days, while Emend is taken over the first three days of each chemotherapy cycle. Additionally, Emend has many drug interactions, including with hormonal birth control, whereas Sustol ER can cause serotonin syndrome if taken with other serotonin-raising medications. Sustol ER is only available as a brand name medication, whereas Emend is available as a low-cost generic.
