Key takeaways
Rizatriptan (Maxalt) and Fioricet (butalbital/acetaminophen/caffeine) are both used to treat headaches, but they work differently and are used for different types of headaches. Rizatriptan is a triptan that treats migraines by tightening blood vessels and reducing inflammation. It is available as a generic and comes in tablet and orally disintegrating tablet (ODT) forms. Fioricet, on the other hand, is a combination medication used for tension headaches. It contains a barbiturate (butalbital), an analgesic (acetaminophen), and caffeine. Fioricet can be habit-forming and is controlled in some states, whereas rizatriptan is not a controlled substance. Rizatriptan is typically taken as needed for migraines, while Fioricet is taken every 4 hours as needed for tension headaches. Both medications can cause drowsiness and dizziness, but Fioricet has a risk of misuse and dependence. Additionally, Fioricet can cause liver damage due to acetaminophen, especially if taken with other acetaminophen-containing medications or alcohol.
