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Maprotiline vs. Doxepin

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Maprotiline and doxepin are both medications used to treat depression and anxiety, but they belong to different classes. Maprotiline was a tetracyclic antidepressant, but is no longer available in the U.S. Doxepin is a tricyclic antidepressant (TCA) that's also FDA-approved for insomnia under the brand name Silenor. The typical dose for doxepin ranges from 75 mg to 150 mg daily. Common side effects of doxepin include drowsiness, dry mouth, and weight gain, and it can cause withdrawal symptoms if stopped abruptly. Doxepin also has specific warnings about worsening depression and suicidal thoughts, especially in people under age 25.

Maprotiline

 

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Doxepin

(Sinequan)

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Summary for Maprotiline

Prescription only

Maprotiline is an antidepressant used to treat depression and anxiety associated with depression. It's no longer available in the United States because it was discontinued.

Indications for Maprotiline

  • Depression
  • Anxiety from depression

Pros and Cons for Maprotiline

Pros

Cons

Summary for Doxepin

Prescription only

Doxepin (Sinequan) is a tricyclic antidepressant (TCA). It comes as a capsule that's taken by mouth to treat depression or anxiety in people over the age of 12. But it's not a first-choice option for these conditions because of the risk of side effects, such as drowsiness, dry mouth, and weight gain. The typical dose of doxepin (Sinequan) ranges from 75 mg to 150 mg by mouth once daily. It's available as a generic capsule and oral solution; the brand name (Sinequan) is discontinued.

Note: Doxepin (Silenor) tablets are FDA-approved for insomnia.

Indications for Doxepin

Pros and Cons for Doxepin

Pros

  • Taken by mouth
  • Typically taken once daily
  • Available as oral capsules and solution

Cons

  • Need to avoid alcohol while taking it
  • Can take 2 to 3 weeks before you notice the full effects for depression
  • Can cause withdrawal symptoms if you stop taking the medication suddenly

Common Side Effects for Doxepin

  • Drowsiness
  • Blurred vision
  • Dry mouth
  • Constipation
  • Trouble passing urine

Warnings for Doxepin

  • Suicidal thoughts or behavior
  • Unmasking of bipolar disorder
  • Serotonin syndrome
  • Drowsiness

Prices with our coupons for Maprotiline vs. Doxepin

Price Card Drug Icon
Maprotiline30 tablets / 50mg
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Price Card Drug Icon
Doxepin30 capsules / 10mg
$10.51$12.34
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