Key takeaways
Lithium (lithium carbonate) and Divalproex (Depakote) are both used to treat bipolar disorder, but they have some key differences. Lithium is a mood stabilizer, while Divalproex is an antiepileptic. Lithium is taken 2 to 3 times a day and comes in various forms, including instant-release pills, oral liquid, and extended-release tablets. Divalproex, on the other hand, is usually taken once or twice daily and is available in delayed-release and extended-release tablets, as well as sprinkle capsules. Lithium requires regular blood tests to monitor levels and prevent toxicity, whereas Divalproex also needs blood tests but mainly to check liver health. Common side effects of lithium include shakiness, thirst, and nausea, while Divalproex can cause nausea, sleepiness, and dizziness. Both medications are available as lower-cost generics. However, Divalproex is not recommended during pregnancy due to the risk of serious birth defects, while lithium is also not recommended but for different reasons, including potential heart issues in the unborn baby.
