Key takeaways
Lisinopril (Zestril) and Zestoretic (lisinopril/hydrochlorothiazide) are both medications used to lower blood pressure, but they have some key differences. Lisinopril (Zestril) is an ACE inhibitor that works by relaxing your blood vessels. It can also treat heart failure and reduce the risk of death after a heart attack. It's available as a tablet and a liquid, and common side effects include cough, dizziness, and headache. On the other hand, Zestoretic combines lisinopril with hydrochlorothiazide, a diuretic that helps remove extra water and certain electrolytes from your body. This combination can cause you to urinate more often and may lead to changes in electrolyte levels, blood sugar, and cholesterol. Both medications are taken once daily and are not safe for use during pregnancy or breastfeeding. While both medications are available in lower-cost generic forms, Zestoretic combines two medications into one convenient pill.
