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Lisdexamfetamine vs. Methylphenidate

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Vyvanse

(lisdexamfetamine)

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Methylphenidate

(Ritalin)

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Summary for Lisdexamfetamine

Prescription only

Vyvanse, the brand name for lisdexamfetamine, is a stimulant medication. It's used to treat attention deficit-hyperactivity disorder (ADHD) in people 6 years and older. It can also treat binge eating disorder (BED) in adults. Vyvanse (lisdexamfetamine) comes as capsules and chewable tablets. It's taken once per day in the morning. The dosage starts low and gets adjusted based on how you respond to the medication. Common side effects include trouble sleeping and loss of appetite. Vyvanse (lisdexamfetamine) is a controlled substance because it has a high risk of misuse and dependency.

Indications for Lisdexamfetamine

Pros and Cons for Lisdexamfetamine

Pros

  • A first-choice ADHD medication
  • Can help with ADHD for up to 14 hours with each dose
  • For binge eating disorder, can lower the number of binge-eating days per week by about one and a half days
  • Has a few options for people who have trouble swallowing pills whole (open the capsule or switch to chewable tablets)

Cons

  • Has a risk of misuse and dependency
  • A controlled medication, so there are special requirements for getting the prescription filled
  • Might need to take gradually lower doses before stopping to avoid withdrawal symptoms
  • Not the best choice for people with heart conditions

Common Side Effects for Lisdexamfetamine

ADHD

Binge eating disorder

  • Dry mouth (36%)
  • Trouble sleeping (20%)

Warnings for Lisdexamfetamine

  • Risk of misuse and addiction
  • Risks to people with serious heart problems
  • Higher blood pressure and faster heart rate
  • Strange thoughts or behavior
  • Slow growth in children
  • Problems with blood flow in the arms and legs, including Raynaud's phenomenon
  • Serotonin syndrome

Summary for Methylphenidate

Prescription only

Methylphenidate hydrochloride (Ritalin) is a stimulant medication that's used for treating attention deficit-hyperactivity disorder (ADHD) and narcolepsy (daytime sleepiness) in adults and children ages 6 years and older. It works by raising the levels of certain chemicals in your brain to keep you focused and awake. The dosage is typically 2 to 3 times per day because it's an immediate-release form of methylphenidate. Side effects of this medication include low appetite, nervousness, and trouble sleeping.

Indications for Methylphenidate

  • Attention deficit-hyperactivity disorder (ADHD)
  • Narcolepsy (daytime sleepiness)

Pros and Cons for Methylphenidate

Pros

  • First-choice medication to treat ADHD in adults and children.
  • Available as a lower-cost generic medication
  • Available as an oral tablet, chewable tablet, and liquid

Cons

  • Is a controlled substance because it has a risk of misuse and dependence
  • Shouldn't stop taking this medication suddenly without talking to your provider first because of greater risk for mood changes
  • Can negatively affect growth in children

Common Side Effects for Methylphenidate

Side effects might differ depending on the formulation. In general:

  • Headache
  • Anxiety
  • Trouble sleeping
  • Low appetite
  • Weight loss

Warnings for Methylphenidate

  • Misuse and dependence
  • Serious heart problems
  • Changes in behavior or thoughts
  • Prolonged and painful erection
  • Blood circulation problem (Raynaud's phenomenon)
  • Slowed growth in children
  • Serotonin syndrome
  • Drug interactions
  • Caution use in people with phenylketonuria (PKU) - chewable tablets only

Prices with our coupons for Lisdexamfetamine vs. Methylphenidate

Price Card Drug Icon
Lisdexamfetamine30 capsules / 30mg
$67.98$389.23
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Methylphenidate60 tablets / 20mg
$26.35$116.82
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