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Lisdexamfetamine vs. Atomoxetine

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Vyvanse

(lisdexamfetamine)

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Atomoxetine

(Strattera)

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Summary for Lisdexamfetamine

Prescription only

Vyvanse, the brand name for lisdexamfetamine, is a stimulant medication. It's used to treat attention deficit-hyperactivity disorder (ADHD) in people 6 years and older. It can also treat binge eating disorder (BED) in adults. Vyvanse (lisdexamfetamine) comes as capsules and chewable tablets. It's taken once per day in the morning. The dosage starts low and gets adjusted based on how you respond to the medication. Common side effects include trouble sleeping and loss of appetite. Vyvanse (lisdexamfetamine) is a controlled substance because it has a high risk of misuse and dependency.

Indications for Lisdexamfetamine

Pros and Cons for Lisdexamfetamine

Pros

  • A first-choice ADHD medication
  • Can help with ADHD for up to 14 hours with each dose
  • For binge eating disorder, can lower the number of binge-eating days per week by about one and a half days
  • Has a few options for people who have trouble swallowing pills whole (open the capsule or switch to chewable tablets)

Cons

  • Has a risk of misuse and dependency
  • A controlled medication, so there are special requirements for getting the prescription filled
  • Might need to take gradually lower doses before stopping to avoid withdrawal symptoms
  • Not the best choice for people with heart conditions

Common Side Effects for Lisdexamfetamine

ADHD

Binge eating disorder

  • Dry mouth (36%)
  • Trouble sleeping (20%)

Warnings for Lisdexamfetamine

  • Risk of misuse and addiction
  • Risks to people with serious heart problems
  • Higher blood pressure and faster heart rate
  • Strange thoughts or behavior
  • Slow growth in children
  • Problems with blood flow in the arms and legs, including Raynaud's phenomenon
  • Serotonin syndrome

Summary for Atomoxetine

Prescription only

Atomoxetine, also known by its brand name Strattera, is a non-stimulant medication. It's used to treat attention-deficit hyperactivity disorder (ADHD) in adults and children ages 6 years and up. Atomoxetine (Strattera) comes as capsules that are swallowed whole. You take your dosage either once or twice a day. Side effects are stomach upset and low appetite. It's not a controlled substance like some ADHD medications are. But atomoxetine (Strattera) still has a few serious risks like behavioral changes and heart problems.

Indications for Atomoxetine

Pros and Cons for Atomoxetine

Pros

  • A good non-stimulant option for both adults and children with ADHD
  • Can take with or without food
  • Not a controlled substance, so there isn't a risk of addiction and it doesn't have special rules when filling a prescription

Cons

Common Side Effects for Atomoxetine

Adults:

  • Nausea (26%)
  • Dry mouth (20%)
  • Low appetite (16%)
  • Trouble sleeping (15%)
  • Feeling tired (10%)

Children:

  • Headache (19%)
  • Stomach pain (18%)
  • Low appetite (16%)
  • Sleepiness (11%)
  • Vomiting (11%)
  • Nausea (10%)

Warnings for Atomoxetine

  • Risk of suicidal thoughts
  • Severe liver damage
  • Serious heart problems
  • Changes in blood pressure and heart rate
  • Aggressive behavior or other changes in behavior
  • Risk of mania in people with bipolar disorder
  • Long-lasting and painful erection
  • Slowed growth in children

Prices with our coupons for Lisdexamfetamine vs. Atomoxetine

Price Card Drug Icon
Lisdexamfetamine30 capsules / 30mg
$67.98$389.23
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Atomoxetine30 capsules / 40mg
$28.28$78.88
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