Key takeaways
Clonidine ER (clonidine) and Adderall (dextroamphetamine/amphetamine salts) are both used to treat attention deficit-hyperactivity disorder (ADHD) in adults and children. However, they belong to different medication classes. Clonidine ER is an alpha-2 adrenergic agonist and is a non-stimulant, while Adderall is a stimulant medication. Clonidine ER is typically taken twice a day, whereas Adderall is taken once or twice a day, depending on the prescribed dose. Clonidine ER is available only as a generic, while Adderall is available as both a brand-name and a generic medication. Common side effects of clonidine ER include sleepiness and headache, while Adderall can cause trouble sleeping and loss of appetite. Both medications can interact with medications like tricyclic antidepressants and blood pressure medications, but Adderall can also interact with medications that affect serotonin levels. Additionally, Adderall is a controlled substance due to its potential for misuse and dependency, while clonidine ER is not.
