Key takeaways
Janumet (sitagliptin/metformin) and Actos (pioglitazone) are both medications used to manage Type 2 diabetes, but they work in different ways and belong to different drug classes. Janumet combines two medications: sitagliptin (a DPP-4 inhibitor) and metformin (a biguanide). It helps control blood sugar by improving insulin function and reducing sugar production in the liver. Actos, on the other hand, is a thiazolidinedione that enhances your body's ability to use insulin. Janumet is taken either twice daily (immediate-release) or once daily (extended-release), while Actos is taken once daily. Janumet is not yet available in a generic form, but a generic version is expected by 2026. Actos is available as a generic. Janumet may cause side effects like diarrhea and upper respiratory infections, whereas Actos can lead to weight gain, fluid retention, and an increased risk of bladder cancer. Both medications have risks, but Janumet is less likely to cause weight gain and low blood sugar compared to other diabetes medications.
