Key takeaways
Guanfacine ER (Intuniv) and methylphenidate ER (Concerta) are both used to treat ADHD, but they belong to different medication classes and work differently. Guanfacine ER is an alpha-2A agonist that lowers norepinephrine levels in the brain and is not a stimulant, making it a good option for those who can't take stimulants. It's typically taken once daily and can cause sleepiness and tiredness. Methylphenidate ER, on the other hand, is a stimulant and works by increasing levels of norepinephrine and dopamine in the brain. It also has a potential for misuse and dependency, so it is a controlled substance. Methylphenidate ER can start working within 2 hours and is also taken once daily, but it may cause trouble sleeping and loss of appetite. Guanfacine ER is available as a lower-cost generic, while Methylphenidate ER comes in various forms, including tablets, capsules, and liquids, with some brands available as generics. Guanfacine ER is only approved for children and adolescents, whereas Methylphenidate ER can be used by both children and adults.
