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Intelence vs. Edurant

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Etravirine (Intelence) and Rilpivirine (Edurant) are both antiretroviral medications used to treat HIV, but they have some key differences. Etravirine (Intelence) is available in both brand-name and generic forms, while Rilpivirine (Edurant) is only available as a brand-name medication. Etravirine (Intelence) is typically taken twice daily after meals, whereas Rilpivirine (Edurant) is taken once daily with a meal, making it more convenient for those with busy schedules. Etravirine (Intelence) is used for people who have developed resistance to other HIV medications, while Rilpivirine (Edurant) is for those who haven't taken HIV medications before and have a viral load of less than 100,000 copies/mL. Both medications can cause severe skin reactions and liver problems, but Rilpivirine (Edurant) also has a risk of depression and suicidal thoughts. Additionally, Etravirine (Intelence) can be used in children as young as 2 years old, while Rilpivirine (Edurant) is only approved for children 2 years and older who weigh at least 30 pounds.

Etravirine

(Intelence)

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Edurant

(rilpivirine)

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Summary for Intelence

Prescription only

Etravirine (Intelence) is a medication that's used as part of an antiretroviral (ARV) therapy to treat human immunodeficiency virus (HIV) infections. It's typically given to people who might've developed resistance to other HIV medications. Etravirine (Intelence) comes as tablets that are swallowed whole or dissolved in liquid for people who have trouble swallowing. Some side effects of this medication are changes in cholesterol levels and rash. Etravirine (Intelence) is available as both a brand-name and generic medication.

Indications for Intelence

  • Treatment of HIV infection in people 2 years of age and older

Pros and Cons for Intelence

Pros

  • Available for people 2 years of age and older who weigh at least 22 lbs
  • Can dissolve tablet with liquid to make it easier for people who have trouble swallowing pills to take
  • No need for dose changes if you're pregnant
  • Might work well for people who didn’t see benefits with other HIV medications in the same class

Cons

  • Need to take twice daily after meals
  • Interacts with many medications, including some other HIV medications (e.g., Tivicay (dolutegravir), atazanavir (Reyataz))
  • Not an option for people who are just starting HIV treatment
  • Doesn't come in a combination pill

Common Side Effects for Intelence

Note: The side effects listed above are from clinical studies with adults taking etravirine (Intelence) and other HIV medications. Side effects might differ in children.

Warnings for Intelence

  • Severe skin and allergic reactions
  • Overactive immune system
  • Changes in body fat
  • Interactions with other medications

Summary for Edurant

Prescription only

Edurant (rilpivirine) is a once-daily antiretroviral medication that's taken by mouth and is used to treat human immunodeficiency virus (HIV) infection. It's approved for use in adults and children. Edurant (rilpivirine) is taken with other antiretroviral medications when it's used for certain people who've never had HIV treatment before. Edurant (rilpivirine) can also be used for a short period of time before starting Cabenuva (cabotegravir / rilpivirine). Side effects of Edurant (rilpivirine) can include depression, headache, and trouble sleeping.

Indications for Edurant

  • Treatment of HIV-1 infection in people 2 years and older, weighing at least 30 pounds, with an HIV viral load of less than 100,000 copies/mL and who haven't taken HIV medications before
  • Short-term treatment of HIV-1 infection in certain people ages 12 years and older, weighing at least 77 pounds, who are planning to start or planning to miss a dose of Cabenuva (cabotegravir / rilpivirine)

Pros and Cons for Edurant

Pros

  • Taken by mouth once a day, so it's convenient for people with a busy schedule
  • Can use in people with mild-to-moderate kidney and liver problems
  • Safe to use during pregnancy

Cons

  • Can cause some allergic skin reactions
  • Must take with a meal
  • Only available as a brand-name medication

Common Side Effects for Edurant

Warnings for Edurant

  • Severe skin reactions and allergic reactions
  • Liver problems
  • Depression and suicidal thoughts
  • Overactive immune system
  • Interaction with other medications

Prices with our coupons for Intelence vs. Edurant

Price Card Drug Icon
Etravirine60 tablets / 200mg
$371.14$1,337.88
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Price Card Drug Icon
Rilpivirine30 tablets / 25mg
$408.82$1,272.11
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