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Etravirine Coupon - Etravirine 200mg tablet

etravirine

Generic Intelence
Used for HIV Treatment
Used for HIV Treatment

Etravirine (Intelence) is a medication that's used as part of an antiretroviral (ARV) therapy to treat human immunodeficiency virus (HIV) infections. It's typically given to people who might've developed resistance to other HIV medications. Etravirine (Intelence) comes as tablets that are swallowed whole or dissolved in liquid for people who have trouble swallowing. Some side effects of this medication are changes in cholesterol levels and rash. Etravirine (Intelence) is available as both a brand-name and generic medication.

Reviewed by:
reviewer
Ally Tsai, PharmD
reviewer
Cydnee Ng, PharmD
Last reviewed on April 26, 2023
BasicsSide effectsPros & consPharmacist tipsFAQsWarningsDosageInteractionsCostAlternativesLatest newsImagesReferencesPricesMedicare
basics-icon

What is Etravirine (Intelence)?

What is Etravirine (Intelence) used for?

  • Treatment of HIV infection in people 2 years of age and older

How Etravirine (Intelence) works

Etravirine (Intelence) is a non-nucleoside reverse transcriptase inhibitor (NNRTI). It blocks an enzyme found in HIV called reverse transcriptase that usually helps the virus make copies of itself. By blocking reverse transcriptase, etravirine (Intelence) prevents the HIV virus from doing so and from spreading.

Drug Facts

Common BrandsIntelence
Drug ClassHIV ARV
Controlled Substance ClassificationNot a controlled medication
Generic StatusLower-cost generic available
AvailabilityPrescription only
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What are the side effects of Etravirine (Intelence)?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

Note: The side effects listed above are from clinical studies with adults taking etravirine (Intelence) and other HIV medications. Side effects might differ in children.

Other Side Effects

  • Upset stomach
  • Gas
  • Constipation
  • Vomiting
  • Blurry vision
  • Dry mouth
  • Dry skin
  • Excessive sweating
  • Feeling like your surroundings are spinning
  • Feeling tired
  • Trouble sleeping
  • Larger breasts in males

Serious Side Effects

Contact your healthcare provider immediately if you experience any of the following.
  • Severe allergic reactions: fever, rash, general discomfort, muscle or joint pain, mouth sores, blisters, facial swelling
  • Liver injury: nausea, vomiting, not feeling hungry, pain in the right side of the stomach, yellowing of the whites of the eyes or skin, dark-colored urine, light-colored stool

Source: DailyMed

The following side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

Rash

Less common

Blurred vision

burning, numbness, tingling, or painful sensations

dizziness

headache

nervousness

pounding in the ears

slow or fast heartbeat

unsteadiness or awkwardness

weakness in the arms, hands, legs, or feet

Rare

Blistering, peeling, or loosening of the skin

chills

cough

diarrhea

fever

hives, itching

hoarseness

irritation

joint pain, stiffness, or swelling

muscle pain

red skin lesions, often with a purple center

red, irritated eyes

redness of the skin

sore throat

sores, ulcers, or white spots in the mouth or on the lips

swelling of the eyelids, face, lips, hands, or feet

tightness in the chest

trouble with breathing or swallowing

unusual tiredness or weakness

Incidence not known

Dark urine

general feeling of tiredness or weakness

headache

light-colored stools

stomach pain, continuing

swollen, painful, or tender lymph glands in the neck, armpit, or groin

vomiting

yellow eyes or skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

Stomach pain

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

pros-and-cons

Pros and cons of Etravirine (Intelence)

thumbs-up

Pros

Available for people 2 years of age and older who weigh at least 22 lbs

Can dissolve tablet with liquid to make it easier for people who have trouble swallowing pills to take

No need for dose changes if you're pregnant

Might work well for people who didn’t see benefits with other HIV medications in the same class

thumbs-down

Cons

Need to take twice daily after meals

Interacts with many medications, including some other HIV medications (e.g., Tivicay (dolutegravir), atazanavir (Reyataz))

Not an option for people who are just starting HIV treatment

Doesn't come in a combination pill

pharmacist-tips

Pharmacist tips for Etravirine (Intelence)

pharmacist

  • Take etravirine (Intelence) after a meal to help your body absorb the medication better.

    • If you have trouble swallowing, dissolve etravirine (Intelence) tablets with 1 teaspoon of water in a cup, and stir well until the mixture looks milky. Then, add 3 teaspoons of liquid (e.g., water, orange juice, milk) to the cup, and drink the mixture right away. Finally, add small amounts of liquid to any leftovers, stir, and drink again to make sure you've taken all the medication.

      • Don't mix etravirine (Intelence) tablets in warm or carbonated drinks. It's not clear how these types of liquids affect how well the medication works.

        • Make sure to get your routine blood tests done on time while you’re taking etravirine (Intelence). This helps your provider make sure the medication is working for you and not causing side effects.

          • Etravirine (Intelence) can cause a life-threatening allergic reaction. If you experience rash with fever, body aches, extreme tiredness, mouth sores, blisters, or facial swelling, get medical attention right away.

            • Let your provider or pharmacist know what medications you're taking or planning to take, including over-the-counter products and supplements. Etravirine (Intelence) can interact with many medications. These interactions can affect how well your medications work or how safe they are for you.

              • If your child is taking etravirine (Intelence), tell their provider if your child experiences any changes in weight. Your child's dose is based on their weight, so the dose might need to be changed depending on how much the change in weight is.

                • Talk to your provider before stopping etravirine (Intelence) or any of your HIV medications. Doing so can cause the virus to spread and become harder to treat.

                  faqs

                  Frequently asked questions about Etravirine (Intelence)

                  When should I take etravirine (Intelence)?
                  Take etravirine (Intelence) twice daily after meals. Taking this medication on an empty stomach might cause it to not work as well. Choose two times during the day that are 12 hours apart to take your medication with a meal. An example schedule might be 8 AM after breakfast and 8 PM after dinner. It's very important to take etravirine (Intelence) regularly according to your provider's instructions. Missing doses can make it easier for the HIV virus to change form, which might make etravirine (Intelence) stop working well for you. And when this happens, the virus can grow and spread in your body. Talk with your provider to find the best schedule for you.
                  Can etravirine (Intelence) be taken alone?
                  No, etravirine (Intelence) shouldn't be taken alone. If you need HIV treatment, your provider will prescribe two other medications along with etravirine (Intelence) to fight the virus and prevent it from spreading. These other medications work differently from etravirine (Intelence) to help lower the amount of virus in the body (viral load). Lowering the HIV viral load helps keep your immune system working. Talk to your provider about what HIV treatment is available to you and whether etravirine (Intelence) is part of your treatment plan.
                  How common is rash with etravirine (Intelence)?
                  Skin rash is a possible side effect of etravirine (Intelence). In clinical studies, 10% of people who took this medication experienced rash. It was extremely rare for people to have a severe rash that was related to life-threatening allergic reactions. If you experience a rash, let your provider know right away. But if you have a rash along with fever, extreme tiredness, muscle or joint pain, blisters, facial swelling, or trouble breathing, stop taking etravirine (Intelence) right away and get medical attention. For severe, life-threatening cases, you might need to be treated in a hospital.
                  Can I take etravirine (Intelence) if I'm pregnant?
                  Let your provider know if you're pregnant or thinking of getting pregnant. They can discuss with you about the risks and benefits of taking etravirine (Intelence). Clinical guidelines recommend that pregnant people with HIV start treatment as soon as possible to lower the risk of transferring the virus to the unborn baby. But etravirine (Intelence) hasn’t been well studied in human pregnancies. One study showed that this medication might have a small chance of causing birth defects in an unborn baby when mothers take it during early pregnancy. If you're pregnant and you're taking etravirine (Intelence), you’re encouraged to enroll in the Antiretroviral Pregnancy Registry (APR). This registry collects information about your and your baby’s health during treatment with etravirine (Intelence). You can learn more about this registry by calling 1-800-258-4263.
                  Can I breastfeed if I'm taking etravirine (Intelence)?
                  The CDC recommends that you avoid breastfeeding your baby if you have HIV. Doing so can raise the risk of spreading the infection to your baby. It's also not recommended for you to breastfeed while you're taking etravirine (Intelence). Etravirine (Intelence) might be found in breast milk. While we don't know how the medication might affect breastfed babies, there's a chance that it can cause side effects, like rash, in your baby. And if your baby is infected with HIV, it's possible that breastfeeding while taking the medication can make your baby's infection harder to treat. Speak to your provider so you can discuss the benefits and risks of breastfeeding while taking etravirine (Intelence).
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                  What are the risks and warnings for Etravirine (Intelence)?

                  Etravirine (Intelence) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

                  risk-warning

                  Severe skin and allergic reactions

                  • Risk factor: Females | Children

                    Etravirine (Intelence) can cause severe skin reactions and allergic reactions that are sometimes life-threatening. In studies, some people developed a rash within the first couple of months of treatment. Watch out for allergic reactions. If you experience a severe rash with fever, general discomfort, muscle or joint pain, mouth sores, blisters, or facial swelling, stop taking etravirine (Intelence) right away and get medical attention.

                    If you have a serious allergic reaction, your provider will probably switch you to a different medication to treat HIV. Your provider might also check your liver function through blood work since severe allergic reactions can sometimes lead to liver injury.

                    risk-warning

                    Overactive immune system

                    Taking combination ARV therapy, such as etravirine (Intelence) with other HIV medications, can cause changes to your immune system called immune reconstitution syndrome. This medical condition happens when your immune system becomes more active after you start combination therapy. Your immune system begins to fight off different infections that it was too weak to fight off before you started treatment. In rare cases, your immune response might improve so much with treatment that it starts to attack normal cells in your body (autoimmune). You can develop immune reconstitution syndrome as early as during the first few weeks of treatment or many months later. Tell your healthcare provider right away if you start having any new symptoms, such as fever, pain, hair loss, bulging eyes, or sweating, after starting etravirine (Intelence).

                    risk-warning

                    Changes in body fat

                    • Risk factors: Taking HIV medications

                      Rarely, people taking HIV medications, such as etravirine (Intelence), have experienced changes in body fat. These changes include fat buildup in the back of the neck, breast, and around the middle of your body. Some people also lost fat from the legs, arms, and face. It's not clear whether etravirine (Intelence) causes these changes to body fat, why this happens, and whether it will affect your health in the future. Let your provider know if these changes occur while you're taking etravirine (Intelence).

                      risk-warning

                      Interactions with other medications

                      Some medications can interfere with how well your body gets rid of etravirine (Intelence) from your system. This can affect the amount of etravirine (Intelence) in your body, how well it works, and the risk of side effects.

                      Taking medications like clarithromycin or fluconazole (Diflucan) can raise the amount of etravirine (Intelence) in your body and raise your risk for serious side effects from the HIV medication. On the other hand, taking certain seizure medications (e.g., carbamazepine (Tegretol)) or the tuberculosis medication rifampin (Rifadin) can lower the amount of etravirine (Intelence) in your body. This can make etravirine (Intelence) not work as well to treat your HIV.

                      Etravirine (Intelence) also interferes with how your body gets rid of other medications. For example, the amount of diazepam (Valium) that your body absorbs can go up when taken with etravirine (Intelence). This can raise your risk of side effects from the sedative, such as sleepiness.

                      Because of the potential for interactions with etravirine (Intelence) and various medications, tell your provider and pharmacist about all the medications you take or plan to take. They can make sure your medications are safe to take together.

                      dosage

                      Etravirine (Intelence) dosage forms

                      The average cost for 180 tablets of 200mg of Etravirine (Intelence) is $545.61 with a free GoodRx coupon. This is 86.38% off the average retail price of $4006.38.
                      tablet
                      Tablet
                      DosageQuantityPrice as low asPrice per unit
                      100mg120 tablets$202.09$1.68
                      200mg180 tablets$545.61$3.03

                      Typical dosing for Etravirine (Intelence)

                      • Adults: The typical dose is 200 mg by mouth twice daily after a meal.

                      • Children age 2 years and older who weigh at least 22 lbs: The dose will depend on your child’s weight. The typical dose ranges from 100 mg to 200 mg by mouth twice daily after a meal.

                      interactions

                      Interactions between Etravirine (Intelence) and other drugs

                      Etravirine (Intelence) may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Etravirine (Intelence). Please note that only the generic name of each medication is listed below.

                      Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

                      Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

                      Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

                      drug-cost

                      How much does Etravirine (Intelence) cost?

                      To access savings, use a GoodRx coupon and pay just a fraction of the retail price.
                      Intelence (brand)
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                      alternatives

                      What are alternatives to Etravirine (Intelence)?

                      There are a number of medications that your doctor can prescribe in place of Etravirine (Intelence). Compare a few possible alternatives below.
                      Etravirine (Intelence)
                      Used for:

                      • Treatment of HIV infection in people 2 years of age and older

                      $202.09 Lowest GoodRx priceView Prices
                      Efavirenz (Sustiva)
                      Used for:

                      • Treatment of HIV infection in people ages 3 months and older

                      $42.58 Lowest GoodRx priceView Prices
                      Isentress (raltegravir)
                      Used for:

                      • Treatment of HIV

                      $1953.41 Lowest GoodRx priceView Prices
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                      Etravirine (Intelence) images

                      White Oblong T200 - Etravirine 200mg Tablet
                      This medicine is White, Oblong Tablet Imprinted With "T200".White Oblong T200 - Etravirine 200mg Tablet
                      White Oval Ac76 - Etravirine 200mg Tablet
                      This medicine is White, Oval Tablet Imprinted With "Ac76".White Oval Ac76 - Etravirine 200mg Tablet
                      White Oval Ac76 - Etravirine 200mg Tablet
                      This medicine is White, Oval Tablet Imprinted With "Ac76".White Oval Ac76 - Etravirine 200mg Tablet

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                      References

                      Best studies we found

                      Centers for Disease Control and Prevention. (2022). HIV treatment as prevention.

                      Centers for Disease Control and Prevention. (2023). Human immunodeficiency virus (HIV).

                      Drugs and Lactation Database (LactMed). (2023). Etravirine.

                      View All References (12)

                      Eraikhuemen, N., et al. (2008). Combating non-nucleoside reverse transcriptase inhibitor resistance with a focus on etravirine (intelence) for HIV-1 infection. P&T: A Peer-Reviewed Journal for Formulary Management.

                      Guidelines for the Use of Antiretroviral Agents in Adults and Adolescents with HIV. (2021). Non-nucleoside reverse transcriptase inhibitor-based regimens. HIV.gov.

                      Guidelines for the Use of Antiretroviral Agents in Adults and Adolescents with HIV. (2022). What to start: Initial combination antiretroviral regimens for people with HIV. HIV.gov.

                      Guidelines for the Use of Antiretroviral Agents in Adults and Adolescents with HIV. (2023). What's new in the guidelines. HIV.gov.

                      HIV/AIDS Glossary. (n.d.). Immune reconstitution inflammatory syndrome (IRIS). HIV.gov.

                      HIV/AIDS Glossary. (n.d.). Non-nucleoside reverse transcriptase inhibitor (NNRTI). HIV.gov.

                      HIV/AIDS Glossary. (n.d.). Reverse transcriptase (RT).

                      HIV.gov. (2021). HIV treatment: Drug resistance.

                      MedlinePlus. (2020). Creatine kinase.

                      Thapa, S., et al. (2023). Immune reconstitution inflammatory syndrome. StatPearls.

                      GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
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