HIV non-nucleoside reverse transcriptase inhibitors (NNRTIs) are used to treat and manage HIV-1 infection. Most HIV NNRTIs are taken in combination with other antiretroviral medications. They work by blocking the reverse transcriptase enzyme, which HIV needs to make copies of itself. These medications are available in oral forms, such as tablets and capsules. Examples include nevirapine (Viramune, Viramine XR), etravirine (Intelence), efavirenz, Edurant (rilpivirine), and Pifeltro (doravirine). Discuss with your HIV specialist to choose a treatment plan that works for you.