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Indocin vs. Feldene

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Indocin (indomethacin) and Feldene (piroxicam) are both NSAIDs used to treat arthritis, but they have some key differences. Indocin is available as a tablet, suspension, and rectal suppository, while Feldene is taken orally as a capsule. Indocin is typically used multiple times a day, whereas Feldene is usually taken once daily. Indocin treats a wider range of conditions, including gouty arthritis and shoulder pain, while Feldene is mainly for osteoarthritis and rheumatoid arthritis. Both medications can cause serious side effects like stomach bleeding and heart problems, but Indocin has additional risks such as worsening mental health issues. Both are available as lower-cost generics.

Indomethacin

(Indocin)

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Piroxicam

(Feldene)

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Summary for Indocin

Prescription only

Indomethacin (Indocin) suppository is an NSAID that's used to treat different types of arthritis and conditions that cause pain in the shoulder. It helps lower inflammation and relieve pain. As a suppository, it's inserted into the rectum, typically 2 to 4 times a day depending on what condition the medication is being used to treat. Side effects might include headache and stomach upset. Unlike other NSAIDs, indomethacin (Indocin) suppository isn't available over-the-counter and requires a prescription from your healthcare provider.

Indications for Indocin

Pros and Cons for Indocin

Pros

  • Good option for people who have trouble swallowing pills
  • Can treat many different types of arthritis
  • Available as a lower-cost generic

Cons

  • Only available in one strength (50 mg), so you might need to use several suppositories if you're taking a high dose
  • Might need to take multiple times per day
  • Not available over-the-counter

Common Side Effects for Indocin

Note: The side effects listed here are for indomethacin capsules. Side effects for the suppositories might differ.

  • Headache
  • Dizziness
  • Nausea
  • Stomach upset

Warnings for Indocin

  • Stomach bleeding and ulcers
  • Heart attack and stroke
  • High blood pressure and heart failure
  • Liver problems
  • Kidney damage and high potassium levels
  • Severe allergic reactions
  • Severe asthma attack
  • Worsening of nervous system and mental health problems
  • Harm to unborn babies

Summary for Feldene

Prescription only

Piroxicam (Feldene) is a nonsteroidal anti-inflammatory drug (NSAID) that works well to relieve symptoms of arthritis, such as joint pain, swelling, and stiffness. It's a capsule that's taken by mouth, typically once daily. Possible side effects include diarrhea, nausea, vomiting, and rash.

Indications for Feldene

Pros and Cons for Feldene

Pros

  • Can be taken once daily
  • Taken by mouth
  • Available as a lower-cost generic

Cons

  • Not available as a liquid
  • Can take 2 to 3 months to get the full effects
  • Can cause serious complications, including stomach bleeding and kidney problems, if taken for a long period of time.

Common Side Effects for Feldene

  • Nausea and vomiting
  • Constipation
  • Passing gas
  • Stomach pain
  • Diarrhea
  • Headache
  • Dizziness
  • Swelling or fluid buildup
  • Rash
  • Ringing in the ears

Please note: The side effects below were reported by up to 10% of people who took piroxicam (Feldene) in clinical trials.

Warnings for Feldene

  • Heart attack and stroke
  • Stomach bleeding and ulcers
  • High blood pressure and heart failure
  • Kidney damage and high potassium levels
  • Liver damage
  • Severe allergic reactions
  • Not for use in pregnant or breastfeeding females

Prices with our coupons for Indocin vs. Feldene

Price Card Drug Icon
Indomethacin1 vial / 1mg
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Piroxicam30 capsules / 10mg
$17.39$41.57
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