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Compare Imcivree vs. Zepbound

Head-to-head comparisons of medication uses, side effects, warnings, and more.

  • Imcivree (setmelanotide)
    Zepbound (tirzepatide)
  • Imcivree (setmelanotide)
    Zepbound (tirzepatide)

  • Summary of Imcivree vs. Zepbound

    Summary for Melanocortin agonist
    Prescription only

    Imcivree (setmelanotide) is an injectable medication for adults and children with certain rare conditions. It's FDA approved for acquired hypothalamic obesity (HO). It's also approved to help with obesity caused by some genetic conditions. These are Bardet-Biedl syndrome (BBS) and POMC, PCSK1, or LEPR deficiency. The medication works as a melanocortin agonist. It lessens appetite and makes the body use more energy, leading to weight loss. It's injected under the skin once a day. Side effects include darkening of skin color and nausea. More serious risks include depression and suicidal thoughts.

    Summary for GIP and GLP-1 agonist
    Prescription only

    Zepbound (tirzepatide) is an injectable medication that's used along with diet and exercise. It helps with weight loss in adults who meet criteria for weight management therapy. It's also approved to treat moderate-to-severe sleep apnea. This medication belongs to the drug class called GIP and GLP-1 agonists. The dosage is 1 injection under the skin once a week. Common side effects include nausea, diarrhea, and injection site reactions. Zepbound (tirzepatide) is only available as a brand-name medication.

  • Indications of Imcivree vs. Zepbound

    Indications for
    •

    Weight loss and long-term weight management in people ages 4 years and older with obesity due to damage to the hypothalamus (acquired hypothalamic obesity, HO)

    •

    Weight loss and long-term weight management in people ages 2 years and older with obesity due to certain genetic conditions:

    •POMC deficiency
    •PCSK1 deficiency
    •Leptin receptor (LEPR) deficiency
    •Bardet-Biedl syndrome (BBS)
    Indications for

    In addition to a balanced diet and exercise plan:

    •Weight loss and long-term weight management in adults considered obese or overweight with at least one weight-related condition (e.g., high blood pressure, Type 2 diabetes)
    •Moderate-to-severe obstructive sleep apnea (OSA) in adults considered obese

  • Pros and Cons of Imcivree vs. Zepbound

    Pros and Const for Melanocortin agonist
    Pros
    •First treatment of its kind for obesity caused by rare genetic conditions (POMC, PCSK1, or LEPR deficiency, and BBS)
    •First FDA-approved medication for obesity caused by problems with the hypothalamus
    •Approved for young children of certain ages
    Cons
    •Must give as an injection under the skin
    •Often causes nausea and vomiting
    •Has a risk of depression or unusual changes in mood, behavior, and thoughts
    Pros and Const for GIP and GLP-1 agonist
    Pros
    •Taken once a week
    •Can take with or without food
    •Has different forms for some people to choose from (vials, single-dose injectable pens, multi-dose KwikPens)
    Cons
    •Must inject under the skin
    •Can cause bothersome side effects, like nausea, diarrhea, and stomach pain
    •Can't use with other tirzepatide products (Mounjaro) or with other GLP-1 agonists

  • Common Side Effects of Imcivree vs. Zepbound

    Common Side Effects for
    •Darkening or discoloration of the skin (58%)
    •Nausea (55%)
    •Vomiting (38%)
    •Headache (37%)
    •Moles (new, larger, or darker ones; 15%)
    •Constipation (12%)
    •Dizziness (12%)
    •Mouth or throat pain (11%)
    Common Side Effects for
    •Nausea (25-29%)
    •Diarrhea (19-23%)
    •Constipation (11-17%)
    •Vomiting (8-13%)
    •Stomach pain (9-10%)
    •Indigestion (9-10%)

  • Warnings of Imcivree vs. Zepbound

    Common Side Effects for
    •Problems with sexual function
    •Depression and suicidal thoughts
    •Allergic reactions
    •Darkening of your skin or moles and appearance of new moles
    •Adrenal insufficiency in people with acquired HO
    •Abnormal sodium levels in people with acquired HO and central diabetes insipidus
    Common Side Effects for
    •Risk of thyroid cancer
    •Stomach problems
    •Kidney damage
    •Gallbladder problems
    •Inflammation of the pancreas (pancreatitis)
    •Allergic reactions
    •Low blood sugar (hypoglycemia)
    •Eye problems in people with Type 2 diabetes (diabetic retinopathy)
    •Lung problems during general anesthesia or deep sedation
    •Don't share Zepound KwikPens with anyone

  • Prices with our coupons for Imcivree vs. Zepbound

    Learn more about Imcivree
    Learn more about Zepbound

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