Key takeaways
Glyburide (Glynase) and Miglitol (Glyset) are both used to help manage blood sugar in people with Type 2 diabetes, but they some differences between them. Glyburide helps your pancreas release more insulin, while Miglitol slows the breakdown of carbohydrates to prevent high blood sugar after meals. Glyburide is usually taken once or twice daily with meals, unlike miglitol which is taken three times a day with meals. Glyburide can cause low blood sugar and weight gain, but miglitol does not cause these issues. However, miglitol can cause gas, diarrhea, and stomach pain, especially when you first start taking it. Both medications are only approved for use in people with type 2 diabetes, but unlike miglitol, glyburide isn't recommended for people who are pregnant.
