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Gentamicin vs. Zyvox

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Gentak (gentamicin) and Zyvox (linezolid) are both antibiotics, but they treat different types of infections and work in different ways. Gentak (gentamicin) is an aminoglycoside antibiotic used to treat bacterial infections of the eye or eyelid, such as pink eye or corneal ulcers. It comes as eye drops or ointment and is applied directly to the infected area. Zyvox (linezolid), on the other hand, is an oxazolidinone antibiotic used to treat more severe infections like pneumonia and skin infections, including those caused by resistant bacteria like MRSA and VRE. Zyvox is available as a tablet, powder for suspension, and injection, and is typically taken every 8 or 12 hours. While Gentak is generally well-tolerated with common side effects like eye irritation, Zyvox has more serious potential side effects, including serotonin syndrome and low blood cell counts. Additionally, Zyvox interacts with certain foods and medications, requiring careful monitoring. Gentak is available in a lower-cost generic form, whereas Zyvox does not mention a generic option.

Gentamicin

 

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Linezolid

(Zyvox)

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Summary for Gentamicin

Prescription only

Gentamicin is a topical antibiotic that treats bacterial skin infections, such as impetigo. It comes as a cream that's useful for wet, oozing, or greasy skin infections. There's also a topical ointment for infections on dry skin. Both forms are applied on the skin 3 to 4 times a day. Gentamicin can be used on adults and children over 1 year of age. Most people don't have many side effects when used as directed. But it's possible to have mild skin irritation, like redness and itching.

Indications for Gentamicin

  • Impetigo
  • Other bacterial skin infections

Pros and Cons for Gentamicin

Pros

  • Treats various bacterial skin infections, including severe acne or impetigo
  • Very few side effects, so it's safe for most people if used as directed
  • Might be a good option for people who are sensitive to Neosporin

Cons

  • Applied many times a day
  • Can cause temporary skin irritation
  • Need a prescription from a healthcare professional

Common Side Effects for Gentamicin

  • Side effects aren't common. See "Other Side Effects."

Warnings for Gentamicin

  • Risk of other skin infections
  • Allergic reaction

Summary for Zyvox

Prescription only

Linezolid (Zyvox) is an oxazolidinone antibiotic that's used to treat adults and children with certain bacterial infections, such as pneumonia and skin infections. This antibiotic can help fight hard-to-treat infections caused by certain bacteria, such as MRSA and VRE. Linezolid (Zyvox) is available as a tablet, powder for suspension, and injection. It's typically taken every 8 or 12 hours. Some side effects include nausea, diarrhea, and headache. This antibiotic also has a rare but serious risk for serotonin syndrome from interactions with medications like antidepressants.

Indications for Zyvox

Pros and Cons for Zyvox

Pros

  • Good choice for treating infections caused by resistant bacteria like MRSA and VRE
  • Available as a tablet, powder for suspension, and injection
  • Can be used in people with kidney or liver problems

Cons

  • Need to take every 8 or 12 hours, depending on your age and infection
  • Can raise the risk of serotonin syndrome when taken with other medications that affect serotonin levels in the body
  • Interacts with some foods, such as aged cheeses, cured meats, and pickled foods

Common Side Effects for Zyvox

Adults

  • Diarrhea (8%)
  • Nausea (7%)
  • Headache (6%)

Children

  • Diarrhea (11%)
  • Vomiting (9%)
  • Anemia (low red blood cell count; 6%)
  • Low platelets (up to 5%)

Warnings for Zyvox

  • Low blood cell counts
  • Nerve and eye damage
  • Serotonin syndrome
  • Diarrhea from Clostridioides difficile infection
  • Buildup of lactic acid in the blood (lactic acidosis)
  • Seizures
  • Low blood sugar
  • Low blood sodium levels
  • Caution use in people with phenylketonuria (PKU) - powder for suspension form only

Prices with our coupons for Gentamicin vs. Zyvox

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Gentamicin2 tubes / 15g of 0.1%
$31.50$99.97
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Linezolid20 tablets / 600mg
$43.89$2,387.61
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