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Flagyl vs. Keflex

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Metronidazole (Flagyl) and cephalexin are both antibiotics, but they belong to different classes and treat different types of infections. Metronidazole is a nitroimidazole antibiotic that treats bacterial and parasitic infections, such as trichomoniasis and bacterial vaginosis. It is taken three times a day and should not be mixed with alcohol due to serious side effects. Cephalexin, on the other hand, is a cephalosporin antibiotic used to treat bacterial infections like UTIs, ear infections, and respiratory infections. It is typically taken 2 to 4 times a day and does not have a direct interaction with alcohol. Metronidazole can cause a metallic taste and in rare cases serious brain and nerve problems, while cephalexin can lead to allergic reactions and C. difficile-related diarrhea. Both medications are available as lower-cost generics and require a prescription.

Metronidazole

(Flagyl)

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Cephalexin

 

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Summary for Flagyl

Prescription only

Metronidazole (Flagyl) is an oral antibiotic for adults and children. It's used to treat certain bacterial and parasitic infections, including bacterial vaginosis (a type of vaginal bacteria infection) and trichomoniasis (a sexually transmitted infection, or STI). Metronidazole (Flagyl) is taken by mouth, typically 3 times a day. Some common side effects of this medication include diarrhea, nausea, and vomiting. Avoid drinking alcohol while taking and for 3 days after stopping metronidazole (Flagyl) because this combination can cause a serious reaction. Metronidazole (Flagyl) is available as a lower-cost generic.

Indications for Flagyl

Treatment of certain bacterial and parasitic infections, including:

Pros and Cons for Flagyl

Pros

  • Taken by mouth
  • Available as a lower-cost generic medication
  • Can be used to treat different types of bacterial infection
  • Immediate-release formulations can be taken with or without food

Cons

Common Side Effects for Flagyl

Please note: These are common side effects reported by people who took extended-release metronidazole (Flagyl)

  • Headache (18%)
  • Inflammation of the vagina (15%)
  • Nausea (10%)
  • Metallic taste (9%)
  • Flu-like symptoms (6%)

Warnings for Flagyl

  • Possible risk of cancer
  • Serious allergic reactions
  • Brain and nerve problems
  • Liver and kidney problems
  • Risk of fungal infection
  • Risk of drug resistance
  • Lower white blood cell counts
  • Interaction with other medications

Summary for Keflex

Prescription only

Cephalexin, also commonly known as Keflex, is a cephalosporin antibiotic for people ages 1 year and older. It can treat many types of bacterial infections. This includes ear infections, skin infections like cellulitis, urinary tract infections (UTIs), and strep throat. Cephalexin comes as capsules, tablets, and a liquid suspension. It's taken by mouth 2 to 4 times per day. Side effects can include nausea, vomiting, and diarrhea. Cephalexin is a generic medication; its brand name Keflex is no longer available.

Indications for Keflex

Pros and Cons for Keflex

Pros

  • Treats several common types of bacterial infections
  • Okay for children as young as 1 year old to take
  • Available as a liquid for people who have trouble swallowing pills

Cons

  • Usually need to take a few times per day
  • Might not be able to take if you're allergic to penicillins or other cephalosporin antibiotics
  • Not recommended for the cold or flu (these are viral illnesses, not bacterial infections)

Common Side Effects for Keflex

  • Diarrhea
  • Nausea
  • Vomiting
  • Indigestion
  • Stomach pain

Warnings for Keflex

  • Allergic reactions
  • Diarrhea from Clostridioides difficile infection
  • Seizures
  • Higher risk of bleeding
  • Possible development of drug-resistant bacteria

Prices with our coupons for Flagyl vs. Keflex

Price Card Drug Icon
Metronidazole14 tablets / 500mg
$8.07$13.97
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Cephalexin28 capsules / 500mg
$11.63$20.36
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