Key takeaways
Methylphenidate extended-release (ER) and Adderall XR (dextroamphetamine/amphetamine salts) are both stimulant medications used to treat attention deficit-hyperactivity disorder (ADHD). They work by increasing levels of norepinephrine, dopamine, and serotonin in the brain. However, they differ in several ways. Methylphenidate ER is available in various forms, such as tablets, capsules, chewable tablets, and liquid, while Adderall XR is available as capsules. Methylphenidate ER is often preferred for children, whereas Adderall XR is commonly used for adults. The typical starting dose for methylphenidate ER is one pill once daily in the morning, while Adderall XR dosing varies by age, with adults typically starting at 20 mg daily. Both medications have a risk of misuse and dependency. Both medications can cause decreased appetite and weight loss, touble sleeping, headaches, and stomach pain. Additionally, both medications can interact with blood pressure medications and monoamine oxidase inhibitors (MAOIs).
