Head-to-head comparisons of medication uses, side effects, warnings, and more.
Key takeaways
Dexmethylphenidate (Focalin, Focalin XR) and Adderall XR (Adderall XR, Mydayis) are both stimulant medications used to treat attention deficit-hyperactivity disorder (ADHD). They work by increasing certain chemicals in the brain, like norepinephrine and dopamine, to help improve focus and attention. Both medications are controlled substances due to their risk of misuse and dependency. However, they differ in several ways. Dexmethylphenidate is available in both immediate-release and extended-release forms, while Adderall XR and Mydayis are only available as extended-release. Dexmethylphenidate is available as a lower-cost generic, whereas Mydayis is only available as a brand medication. The starting doses and maximum doses also vary between the two medications. Common side effects for both include trouble sleeping and loss of appetite, but dexmethylphenidate can also cause stomach upset and nervousness, while Adderall XR may lead to dry mouth and weight loss. Both medications can interact with other drugs, especially those affecting serotonin levels, and should not be taken with monoamine oxidase inhibitors (MAOIs).
Focalin (dexmethylphenidate)
Adderall xr
Focalin (dexmethylphenidate)
Adderall xr
Summary of Focalin vs. Adderall XR
Summary for Stimulant
Prescription only
Dexmethylphenidate (Focalin, Focalin XR) is a stimulant medication that's used for treating attention deficit-hyperactivity disorder (ADHD) in adults and children. It's thought to work by balancing certain chemicals in your brain to help you focus. This medication is available as an immediate-release tablet that you take twice per day and an extended-release capsule you take once per day. Side effects can include stomach upset and nervousness. It can also cause withdrawal symptoms if it's suddenly stopped after long-term use. Focalin (dexmethylphenidate) is available as both a brand-name and lower-cost generic medication.
Summary for Stimulant
Prescription only
Adderall XR is the extended-release version of dextroamphetamine and amphetamine salt combo. It's a stimulant used to treat attention deficit-hyperactivity disorder (ADHD) in people 6 years and older. It comes as a capsule that you take once a day in the morning. The prescriber can adjust the dosage depending on how well it helps you focus and if you have side effects that bother you. These side effects can include low appetite, stomach pain, and trouble sleeping. It's a controlled substance because of its high risk of misuse and dependency. Adderall XR is available as a brand-name medication and a generic.