Key takeaways
Baclofen (Ozobax DS, Fleqsuvy, Lyvispah) and tizanidine (Zanaflex) are both prescription muscle relaxers used to treat muscle spasms and stiffness. Baclofen is typically used for muscle spasms from multiple sclerosis or spinal cord injuries, whereas tizanidine is used for muscle stiffness and rigidity. Baclofen is available in tablets, oral solutions, and dissolvable granules, while tizanidine comes in tablets and capsules. Both medications are usually taken three times a day, with baclofen doses ranging from 5 mg to 20 mg and tizanidine doses from 2 mg to 36 mg per day. Baclofen can cause side effects like sleepiness, dizziness, and nausea, while tizanidine can cause low blood pressure, dry mouth, and sleepiness. Both medications interact with some other medications. Always be sure your prescriber and pharmacist have a complete list of your medications.
