Key takeaways
Fexofenadine (Allegra) and cetirizine (Zyrtec) are both second-generation antihistamines used to relieve allergy symptoms like runny nose, itchy eyes, and hives. But they have several differences between them. Fexofenadine is available over-the-counter (OTC) in various forms, including tablets, orally disintegrating tablets, and liquid, and is typically taken once or twice a day. Cetirizine is also available OTC and comes in a variety of forms such as tablets, chewable tablets, and liquid solutions, and is usually taken once a day. One key difference is that fexofenadine is less likely to cause drowsiness compared to cetirizine. Additionally, cetirizine is considered safe for use during pregnancy, while fexofenadine should be discussed with a healthcare professional if you are pregnant or breastfeeding. Both medications should not be taken with other antihistamines to avoid the risk of overdose and severe side effects.
