HIV integrase strand transfer inhibitors are used to treat and manage HIV infection. Some medications prevent HIV infection in people at high risk for HIV. These medications work by blocking the HIV integrase enzyme, which is important for the virus to make copies of itself and spread in your body. Some of these medications come in oral forms, while others are available as injectables. Examples include Tivicay (dolutegravir), Isentress (raltegravir), Apretude (cabotegravir), and Vocabria (cabotegravir). Work with your HIV specialist to decide which medication best fits your needs.