5 Foods to Avoid When Taking Letrozole
There aren’t any specific foods to avoid while taking letrozole. However, maintaining a nutritious diet and limiting alcohol can minimize the risk of some effects.
letrozole
Used for Breast Cancer
Used for Breast Cancer
Letrozole (Femara) is an aromatase inhibitor, a type of hormonal therapy. It’s FDA-approved to treat or prevent breast cancer in females who’ve already gone through menopause. It’s sometimes prescribed off-label by fertility specialists to help females become pregnant. Letrozole (Femara) is taken by mouth, typically once a day for breast cancer. Common side effects include hot flashes and pain in the bones, muscles, and joints.
What is Letrozole (Femara)?
What is Letrozole (Femara) used for?
- Breast cancer in females who have already gone through menopause:
- Preventing breast cancer from coming back (hormone receptor-positive early breast cancer), sometimes after treatment with tamoxifen (Nolvadex)
- Treatment of advanced or metastatic breast cancer
How Letrozole (Femara) works
Certain types of breast cancer cells grow when there is estrogen present. Aromatase is a protein in the body involved in making estrogen.
Letrozole (Femara) is an aromatase inhibitor that works by blocking aromatase. In doing so, letrozole (Femara) prevents breast cancer cells from getting the estrogen that’s fuel for the cancer to grow and spread.
Drug facts
| Common Brands | Femara |
|---|---|
| Drug Class | Aromatase inhibitor |
| Controlled Substance Classification | Not a controlled medication |
| Generic Status | Lower-cost generic available |
| Availability | Prescription only |
More on Letrozole (Femara) essentials
Side effects of Letrozole (Femara)
The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
- High blood cholesterol levels (52%)
- Hot flashes (34%)
- Muscle, bone, or joint pain (25%)
Note: Side effects reported by females who took letrozole (Femara) after surgery for early breast cancer.
Less Common Side Effects
- Bone fractures
- Night sweats
- Weight gain
- Nausea
More on Letrozole (Femara) side effects
The following Letrozole (Femara) side effects have also been reported
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
Less common
Bone fracture
breast pain
chills, fever, or flu-like symptoms
mental depression
swelling of the feet or lower legs
Rare
Continuing or severe nervousness
dizziness or lightheadedness
fainting
fast heartbeat
increased sweating
pain in the chest, groin, or legs, especially the calves
severe and sudden, unexplained troubled breathing
severe, sudden headache
slurred speech
sudden loss of coordination
sudden, severe weakness or numbness in the arm or leg
swollen glands
vaginal bleeding
vision changes
Incidence not known
Black, tarry stools
blindness
blurred vision
burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
chest discomfort
dark urine
decreased vision
dilated neck veins
extreme tiredness or weakness
general tiredness or weakness
increased need to urinate
irregular breathing
irregular heartbeat
light-colored stools
painful or difficult urination
passing urine more often
sores, ulcers, or white spots on the lips or in the mouth
unusual bleeding or bruising
unusual tiredness or weakness
upper right abdominal pain
white or brownish vaginal discharge
yellow eyes and skin
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Less common
confusion
headache
increased thirst
loss of appetite or weight loss
metallic taste
skin rash or itching
sleepiness
spinning or whirling sensation causing loss of balance
stomach pain or upset
trouble sleeping
vomiting
weakness
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
Get your GoodRx coupon
$173.48
GoodRx discount
$8.91
Pros and cons of Letrozole (Femara)
Pros
- Can be used during early and advanced stages of breast cancer
- Taken by mouth once daily
- Available as a lower-cost generic
Cons
- Only for females who've reached menopause (for treating breast cancer)
- Can cause menopausal symptoms, such as hot flashes and night sweats
- Can weaken your bones if taken long-term
Pharmacist tips for Letrozole (Femara)
- Take letrozole (Femara) dose around the same time each day, with or without a meal.
- Letrozole (Femara) can cause fatigue, dizziness, and sleepiness. Do not drive or operate machinery until you know how the medication affects you.
- Letrozole (Femara) can cause side effects similar to menopausal symptoms, like hot flashes, night sweats, and headaches. Try to avoid alcohol, caffeine, or smoking, because they can worsen these symptoms.
- Letrozole (Femara) can weaken your bones, which makes it easier to break. Ask your oncology care team if you need to take calcium or vitamin D while taking letrozole (Femara) to strengthen your bones.
- Letrozole (Femara) can raise cholesterol levels in the blood. If your cholesterol gets too high, it can lead to serious heart disease. Your oncologist might routinely check your cholesterol levels to make sure that they're within safe range.
Risks and warnings for Letrozole (Femara)
Letrozole (Femara) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Weakened bones
- Risk factors: Ages 65 years and older Taking letrozole (Femara) for longer periods of time (2 years or longer) can lower bone mineral density (BMD), raising the risk for fractures. This risk is higher if you take letrozole (Femara) or other medications that can lower BMD for a long time, or if you have other factors that raise your risk for brittle bones (osteoporosis). Before starting treatment, your provider will likely have you do a scan to check on your bones, and repeat those scans every couple years during treatment. They might also recommend medications to prevent bone loss, such as zoledronic acid (Zometa) or denosumab (Xgeva).
High cholesterol levels
One of the more common side effects of letrozole (Femara) is higher levels of cholesterol in the blood. Over time, this can raise the risk for heart attacks and strokes. To lower this risk, your oncology care team will help you plan nutritious meals and exercise routines that you can do regularly. Your oncologist will check on your cholesterol levels before you start letrozole (Femara) and periodically during treatment. If they notice your cholesterol levels rising, they might have you start medications to lower your cholesterol levels.
Liver problems
- Risk factors: Severe liver disease and liver dysfunction
The liver is responsible for breaking down letrozole (Femara) in your body. If there is a problem with your liver, it can lead to high levels of letrozole (Femara) in your body and raise your risk of side effects. Let your oncology care team know if you have an existing liver problem, because your oncologist might have to lower your dose of letrozole (Femara).
Risk of drowsiness
Letrozole (Femara) can cause sleepiness, which can lower your ability to think, react, and focus. Your risk might be higher if you're taking other medications that can cause you to feel sleepy (e.g., benzodiazepines, muscle relaxants, sleep medications). Make sure you know how this medication affects you before driving a car or doing activities that require your concentration. Talk to your healthcare provider right away if you feel too sleepy from taking letrozole (Femara).
Harm to unborn baby
It's unlikely that pregnancy can happen after menopause, but if you think you could be pregnant, let your oncology care team know. Letrozole (Femara) can cause harm to an unborn baby. If there's a chance that you still have the ability to get pregnant, use an effective birth control while taking letrozole (Femara) and for at least 3 weeks after your last dose.
Letrozole (Femara) dosage
The average cost for 10 tablets of 2.5mg of Letrozole (Femara) is $8.91 with a free GoodRx coupon. This is 94.86% off the average retail price of $173.48. 
Tablet
Tablet| Dosage | Quantity | Price as low as | Price per unit |
|---|---|---|---|
| 2.5mg | 10 tablets | $8.91 | $0.89 |
Typical dosage for Letrozole (Femara)
The typical dose is 2.5 mg by mouth daily. Your oncology care team will determine how long your treatment should last.
Your oncologist might lower your dose if you have a history of liver problems.
Interactions between Letrozole (Femara) and other drugs
Letrozole (Femara) may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Letrozole (Femara). Please note that only the generic name of each medication is listed below.
More on Letrozole (Femara) interactions
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Ceritinib
- Cilostazol
- Clarithromycin
- Tegafur
How much does Letrozole (Femara) cost?
To access savings, use a GoodRx coupon and pay just a fraction of the retail price.
What are alternatives to Letrozole (Femara)?
There are a number of medications that your doctor can prescribe in place of Letrozole (Femara). Compare a few possible alternatives below.
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Letrozole (Femara) images
