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Heartburn

Have Heartburn That Won't Go Away? Your Heartburn Could Be Something Else

Katie E. Golden, MDSophie Vergnaud, MD
Written by Katie E. Golden, MD | Reviewed by Sophie Vergnaud, MD
Updated on March 3, 2025

Key takeaways:

  • Heartburn is usually a symptom of acid reflux. But other health conditions can cause heartburn pain too. Heart attacks and stomach ulcers are two examples.

  • Even if your heartburn is from acid reflux, this isn’t a harmless condition. Frequent episodes may mean you have GERD (gastroesophageal reflux disease), which can have long-term health complications.

  • If you have heartburn that won’t go away, seek medical attention. It can be nearly impossible to tell what’s causing your heartburn based on symptoms alone.

When you’re experiencing heartburn, you may take an antacid and forget about it. And many times, heartburn is truly just an episode of acid reflux. 

But it can also be a symptom of something more serious. If you’re experiencing frequent or severe episodes of heartburn, it’s important to consider if something else could be going on. 

Here, we’ll run through some other conditions that can cause or feel like heartburn. More importantly, we’ll help you figure out if it’s time to go to the doctor’s office or emergency room (ER).

What is heartburn?

Featuring Roshini Raj, MDReviewed by Karen Hovav, MD, FAAP | April 5, 2025

Heartburn is a symptom that feels like a burning sensation in your chest. Many times, this is caused by acid reflux. Acid reflux occurs when acid in the stomach flows up into your esophagus. The esophagus isn’t meant to be exposed to this acid. So, it can irritate the esophagus lining and cause pain. 

Is acid reflux and heartburn the same?

Many people use the term heartburn and acid reflux interchangeably. But they aren’t exactly the same thing. Technically speaking, heartburn is the symptom. Acid reflux is the process happening in the stomach and esophagus.

What causes acid reflux?

Certain medical conditions can cause acid reflux. One of the most common conditions is GERD (gastroesophageal reflux disease), which we cover in the next section. 

But acid reflux isn’t always caused by an underlying medical condition. It can happen on occasion to anyone. Some things that can cause acid reflux are:

For many people, acid reflux happens every once in a while. But if it occurs two or more times a week, it might be a sign of GERD.

What is GERD?

GERD is a condition that causes frequent episodes of acid reflux. It often happens because the sphincter (ring of muscles) between your esophagus and stomach doesn’t close properly. Without a tight closure, contents of the stomach can travel up into your esophagus.

The classic symptoms of GERD include:

  • Heartburn

  • Pain in the center of the chest

  • Difficulty swallowing

  • A sour taste in the mouth

  • Bad breath

  • Sensation like there’s a lump in your throat

  • Cough

  • Nausea or vomiting

  • Sore throat and hoarseness

  • Bloating, gas, and belching

Is heartburn from GERD serious?

It can be. Beyond the impact on your quality of life, untreated GERD can lead to long-term damage to the esophagus. This can lead to:

What is the difference between GERD and acid reflux?

All these overlapping terms can get confusing. So, here’s a quick review:

  • Heartburn is a symptom of chest burning, often caused by acid reflux.

  • Acid reflux is when stomach acid travels up into the esophagus.

  • GERD is when episodes of acid reflux happen over and over again.

But not everyone with GERD has heartburn. And not everyone with heartburn has GERD. 

Quiz: Is it acid reflux or a heart attack?

Conditions that can mimic heartburn

Many different conditions can cause heartburn. Below, we go through some conditions that:

  • Feel like acid reflux — but aren’t

  • Cause acid reflux — but are different from GERD

Heart attack

A heart attack can cause chest pain that feels similar to heartburn. It can be hard to tell the difference based on the pain alone. In fact, even healthcare professionals can’t predict whether someone’s chest pain is coming from the heart or stomach. 

Some additional symptoms of a heart attack include:

  • Heaviness or pressure in the chest 

  • Pain that worsens with exertion

  • Discomfort in the left shoulder, arm, or jaw

  • Shortness of breath 

  • Clammy skin or cold sweats

  • Dizziness and feeling lightheaded

  • Nausea

But not everyone will have these symptoms. Don’t try and figure it out on your own. It’s important to take any type of chest pain seriously and get it checked out by a healthcare professional. 

Gastritis

Gastritis is irritation in the lining of the stomach. So, gastritis and acid reflux can feel similar — and share some common causes. Medications like NSAIDs, dietary habits, and certain health conditions can lead to either one. But most often, gastritis is often caused by a long-term bacterial infection in the stomach called Helicobacter pylori (H. pylori). 

It’s important to diagnose and treat gastritis. Otherwise, it can lead to complications like bleeding, ulcers, and stomach cancer.

Peptic ulcers

Peptic ulcers are sores that develop in either the :

  • Lining of the stomach (which is known as a gastric ulcer)

  • First part of the intestine (which is a duodenal ulcer) 

Like gastritis, there’s a lot of overlap between GERD and ulcers. But they’re different conditions, with different causes and complications.

Symptoms of a peptic ulcer include:

  • A deep, gnawing pain around the stomach

  • Burning pain, which can get worse or better with eating

  • Decreased appetite

  • Weight loss

  • Bloating

  • Vomiting of bright red or dark blood

  • Sticky, black stools

Without treatment, ulcers can erode a hole in the stomach or intestine. This is a life-threatening emergency that usually causes severe abdominal pain.

Gallstones 

Sometimes, pain that gets worse after you eat isn’t heartburn — it may be gallstones. These are hard collections of cholesterol that form in the gallbladder, an organ that sits right next to the stomach.

The gallbladder is located on the right side of the abdomen. So, many people feel gallstone pain underneath the right ribs or around the stomach. But you may feel it in your chest too. Gallstone pain can also:

  • Come on suddenly

  • Radiate to the back or right shoulder

  • Trigger nausea and vomiting

For some people, the biggest problem with gallstones is that they’re very painful. But gallstones can also lead to some health complications. If they get lodged in the wrong place, they can lead to serious infections of the gallbladder. They can also lead to a painful condition called pancreatitis, an inflammation of the pancreas. Pancreatitis tends to cause severe pain around the stomach.

Gastroparesis

If you have gastroparesis, it takes much longer for food to pass from your stomach into your intestine. This delay in digestion can increase the chance of acid reflux. So it can trigger heartburn symptoms, although the underlying cause is different from GERD. 

Other signs and symptoms are more unique to gastroparesis, such as:

  • Feeling full after a few bites

  • Vomiting undigested food

  • Weight loss and malnutrition

There are different causes of gastroparesis — from diabetes to medications like GLP-1 agonists. Gastroparesis can have a significant impact on your quality of life and nutrition, and there are plenty of treatment options. So it’s important to see a healthcare professional if you have this condition.

Hiatal hernia

A hiatal hernia is a type of hernia that occurs inside the chest. The top part of the stomach can sometimes slide upward, through a hole in the diaphragm. This pushes more of the stomach into the chest area, which can increase the likelihood of acid reflux.

Hiatal hernias are common. They affect up to 1 in 5 people. And they aren’t necessarily a cause for concern. Many people don’t have any problems or symptoms with a hiatal hernia. But when it causes GERD, it’s important to get treatment.

Other conditions

The above list is by no means a full list of all the conditions that can mimic heartburn. Examples of other conditions include:

The takeaway is that you shouldn’t try to figure out the cause of your heartburn alone. Ask a trusted healthcare professional for help.

When should I see a healthcare professional about heartburn?

Featuring Roshini Raj, MDReviewed by Sanjai Sinha, MD | April 5, 2025

If you’re questioning if your heartburn is acid reflux or something else, that’s a good reason to see a healthcare professional. Many different things can cause chest pain. And it can be hard to tell the difference between something harmless or serious. Gas can feel like a heart attack, and a heart attack can feel like gas. 

Before we go into reasons to see your healthcare team, here are some reasons to go straight to the ER for chest pain:

  • You feel like you’re having a heart attack, regardless of your symptoms.

  • It feels like heartburn that won’t go away, or is getting worse.

  • You have pain that feels severe.

  • You have pain in your arms, neck, back, or jaw.

  • Physical effort makes the pain worse.

  • You have trouble breathing.

  • You have cold sweats.

  • You’re vomiting blood.

But even if you’re pretty sure your heartburn is from acid reflux, this isn’t a harmless condition. Long-standing reflux can lead to health complications. Contact your healthcare team right away if you have:

  • Heartburn two or more times a week

  • Difficulty swallowing

  • Hoarseness

  • Vomiting

  • Unintended weight loss

  • Dark or bloody stools (if you’re having a lot, go to the ER for that too)

  • Symptoms that wake you up at night

The bottom line

Heartburn is a common symptom. But there are times when you shouldn’t ignore it. Heartburn can be a warning sign of a more serious or long-term condition. So, if you find yourself reaching for an antacid more frequently, it’s a good time to talk to your healthcare team. They can make sure you don’t need any testing to look for other causes. And even if there’s nothing more serious going on, they can offer treatment to help your symptoms. 

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Why trust our experts?

Katie E. Golden, MD, is a board-certified emergency medicine physician and a medical editor at GoodRx.
Sophie Vergnaud, MD, is the Senior Medical Director for GoodRx Health. A pulmonologist and hospitalist, she practiced and taught clinical medicine at hospitals in London for a decade before entering a career in health education and technology.

References

Bösner, S., et al. (2010). Accuracy of general practitioners’ assessment of chest pain patients for coronary heart disease in primary care: Cross-sectional study with follow-up. Croatian Medical Journal

Chang, P., et al. (2013). Obesity & GERD. Gastroenterology Clinics of North America

GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.

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