Key takeaways:
Voquezna (vonoprazan) is a medication that treats conditions related to excess stomach acid. The typical Voquezna dosage is 10 mg to 20 mg daily, depending on the condition you’re taking it for.
You can also take Voquezna 20 mg twice daily, along with one or two antibiotics, to treat Helicobacter pylori (H. pylori) infections. In this case, it comes in daily dose packs to help you know what medications to take and when to take them.
You may need to take a lower Voquezna dosage or avoid it altogether if you’re living with kidney or liver problems. Your prescriber will help you decide on the best treatment option for your needs.
Save on related medications
Voquezna (vonoprazan) is a medication that treats gastroesophageal reflux disease (GERD) and other issues related to excess stomach acid. It’s also paired with antibiotics to help treat Helicobacter pylori (H. pylori) infections. Voquezna is only FDA approved for adults at this time.
Knowing the right Voquezna dosage for your needs can help you get the most from the medication. Here’s what you should know.
What dosage forms does Voquezna come in?
Voquezna comes in three different products:
Voquezna: 10 mg and 20 mg tablets
Voquezna Dual Pak: Voquezna 20 mg tablets / amoxicillin 500 mg capsules
Voquezna Triple Pak: Voquezna 20 mg tablets / amoxicillin 500 mg capsules / clarithromycin 500 mg tablets
You can take Voquezna with or without food. But some people find that taking it with food helps reduce stomach upset — a common side effect of the medication. You must swallow Voquezna tablets whole; they can’t be chewed or crushed. So you may need a different treatment option if you have trouble swallowing pills.
What’s the typical Voquezna dosage for adults?
The recommended Voquezna dosage depends on the condition you’re treating.
Healing and maintenance of erosive esophagitis
To heal erosive esophagitis, the recommended Voquezna dosage is 20 mg once daily for 8 weeks. Once your esophagus has healed, a lower Voquezna dosage of 10 mg once daily is recommended for up to 6 months.
GERD
To relieve heartburn related to GERD, the recommended Voquezna dosage is 10 mg once daily for 4 weeks. Keep in mind that this dosage only applies if you have nonerosive GERD. If there are signs of damage to your esophagus, you’ll likely require a higher Voquezna dosage.
Treating H. pylori infections
Voquezna isn’t approved to treat H. pylori infections on its own. Instead, you’ll take it along with one or two antibiotics to treat your stomach infection. The recommended dosages are:
Voquezna Dual Pak: Voquezna 20 mg twice a day (morning and evening) plus amoxicillin 1,000 mg (two 500 mg capsules) three times a day for 14 days
Voquezna Triple Pak: Voquezna 20 mg, amoxicillin 1,000 mg (two 500 mg capsules), and clarithromycin 500 mg twice daily (about 12 hours apart) for 14 days
Voquezna Dual and Triple Pak both come with daily dose cards. Each card contains the pills for 1 day of treatment and is labeled with clear instructions as to when to take each pill.
Are there any dosage adjustments for medical conditions?
Your Voquezna dosage may need adjusting based on your kidney or liver health.
Dosage for people with kidney problems
If you’re living with kidney problems, you may need a lower Voquezna dosage. This will likely be based on your glomerular filtration rate (GFR), a measure of how well your kidneys are working. If your GFR is less than 30 mL/min, you shouldn’t take more than 10 mg of Voquezna daily on its own, and taking it for H. pylori treatment isn’t recommended.
Voquezna (vonoprazan) 101: Learn how Voquezna works and why it may be a game changer for people with gastroesophageal reflux disease (GERD).
Erosive esophagitis diet: Learn which foods to avoid and how to make eating easier if you’re living with erosive esophagitis.
Fast relief from acid reflux: Follow these tips to help relieve heartburn symptoms quickly.
Dosage for people with liver problems
If you’re living with liver problems, you may also need a lower Voquezna dosage. This is typically based on a rating called the Child-Pugh score. Those considered Child-Pugh class B or C shouldn’t take more than 10 mg of Voquezna daily. Taking it for H. pylori treatment isn’t recommended for these groups.
What happens if you miss a dose of Voquezna?
If you’re taking Voquezna for GERD or erosive esophagitis and you miss a dose, take the medication as soon as you remember if it’s been less than 12 hours. If more than 12 hours have passed since your missed dose, skip it and resume your usual dosage schedule.
If you’re taking Voquezna for an H. pylori infection and you miss a dose, take it as soon as possible, as long as it’s within 4 hours of the missed dose. If it’s been more than 4 hours, skip the missed dose and take your next dose as scheduled.
What should you do if you take too much Voquezna?
If you take an extra dose of Voquezna by mistake, it's not likely to cause a major issue. But you may experience increased side effects, such as upset stomach or diarrhea.
We don’t have much information on the risks of taking a large amount of Voquezna. If this happens, it’s best to reach out to your prescriber or contact Poison Control for guidance. You can speak with Poison Control online or at 1-800-222-1222. If you develop any symptoms that seem severe or life-threatening, seek emergency medical care.
How to save on Voquezna
There are ways to save on Voquezna, which is available as a brand-name medication. GoodRx can help you navigate between GoodRx coupons and copay savings cards to save money on your prescription:
Save with GoodRx. Anyone with a valid prescription, regardless of insurance status, can use GoodRx to purchase a 30-day supply of Voquezna at an exclusive cash price of around $199.
Save with a copay savings card. If you have commercial insurance, you may be eligible to pay as little as $25 for a 30-day supply of Voquezna using a savings card from the manufacturer.
The bottom line
Voquezna (vonoprazan) is a medication that treats conditions related to excess stomach acid. The typical Voquezna dosage is 10 mg to 20 mg daily, depending on the condition you’re taking it for. You can also take Voquezna 20 mg twice daily, along with one or two antibiotics, to treat H. pylori infections. In this case, it comes in daily dose packs to help you know what medications to take and when to take them.
You may need to take a lower Voquezna dosage or avoid it altogether if you’re living with kidney or liver problems. Your prescriber will help you decide on the best treatment option for your needs.
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References
MedlinePlus. (2024). Vonoprazan.
Phathom Pharmaceuticals. (2025). Voquezna Duak Pak - vonoprazan fumarate and amoxicillin, Voquezna Triple Pak - vonoprazan fumarate, amoxicillin and clarithromycin [package insert].
Phathom Pharmaceuticals. (2025). Voquezna - vonoprazan fumarate tablet [package insert].
Tsoris, A., et al. (2023). Use of the Child Pugh score in liver disease. StatPearls.
Vaezi, M. F., et al. (2022). Patient journey in erosive oesophagitis: Real-world perspectives from US physicians and patients. BMJ Open Gastroenterology.
