provider image
Welcome! You’re in GoodRx for healthcare professionals. Now, you’ll enjoy a streamlined experience created specifically for healthcare professionals.
Skip to main content
Voquezna Coupon - Voquezna 20mg tablet

Voquezna

vonoprazan
Used for Heartburn
Used for Heartburn

Voquezna (vonoprazan) is a potassium-competitive acid blocker (PCAB). It relieves heartburn from erosive esophagitis and non-erosive gastroesophageal reflux disease (GERD). It can also treat H. pylori infections, in combination with certain antibiotics. Voquezna (vonoprazan) received FDA approval in late 2023 for adults and is available as a tablet that's taken by mouth once per day. Side effects aren't common, but can include stomach pain and indigestion. Voquezna (vonoprazan) is typically taken short-term to prevent more serious side effects, like bone fractures and infectious diarrhea.

Last reviewed on January 23, 2024
basics-icon

What is Voquezna (vonoprazan)?

What is Voquezna (vonoprazan) used for?

How Voquezna (vonoprazan) works

Voquezna (vonoprazan) is a potassium-competitive acid blocker (PCAB). It blocks a protein to stop stomach acid from being made and released into your stomach. This prevents stomach acid from irritating your stomach.

Drug Facts

Common BrandsVoquezna
Drug ClassPotassium-competitive acid blocker (PCAB)
Controlled Substance ClassificationNot a controlled medication
Generic StatusNo lower-cost generic available
AvailabilityPrescription only

More on Voquezna (vonoprazan) essentials

coupon-save-icon

Get your GoodRx coupon

Avg retail price
$817.50(save 96.94%)
Sponsored copay card
Subject to eligibility
$25.00
See prices
basics-icon

What are the side effects of Voquezna (vonoprazan)?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Stomach inflammation (up to 6%)
  • Stomach pain (up to 4%)
  • Indigestion (up to 4%)

Other Side Effects

  • Urinary tract infection
  • Nausea
  • Bloating

Serious Side Effects

Contact your healthcare provider immediately if you experience any of the following.
  • Serious kidney problems: bloody urine, fever, sleepiness, confusion, rash, nausea, vomiting, fluid build-up
  • Infectious (C. difficile-related) diarrhea: rapid heart rate, foul-smelling diarrhea, fever, nausea, frequent bowel movements (even up to 15 times per day)
  • Severe skin reaction: painful rash, blisters, peeling skin, fever, flu-like symptoms

Source: DailyMed

The following side effects have also been reported

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
  • Kidney injury—decrease in the amount of urine, swelling of the ankles, hands, or feet
  • Low magnesium level—muscle pain or cramps, unusual weakness or fatigue, fast or irregular heartbeat, tremors
  • Low vitamin B12 level—pain, tingling, or numbness in the hands or feet, muscle weakness, dizziness, confusion, trouble concentrating
  • Redness, blistering, peeling, or loosening of the skin, including inside the mouth
  • Severe diarrhea, fever

Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):

pros-and-cons

Pros and cons of Voquezna (vonoprazan)

thumbs-up

Pros

Taken by mouth

Starts to work within 2-3 hours

Can take with or without food

thumbs-down

Cons

Not available as a generic

No liquid version available for those who can't swallow pills

Available by prescription only

pharmacist-tips

Pharmacist tips for Voquezna (vonoprazan)

pharmacist
  • Voquezna (vonoprazan) can be taken with or without food. If it's upsetting your stomach, try taking it with food to help.

    • Let your provider know if your heartburn symptoms aren't getting better or worsen after taking Voquezna (vonoprazan). They might ask you to get tested for a more serious stomach problem.

      • Voquezna (vonoprazan) can interact with a lot of medications, especially those that need an acidic environment in your stomach for better absorption into your body. Make sure to tell you provider about all of the medications you're taking before starting Voquezna (vonoprazan).

        • If you're taking Voquezna (vonoprazan) once daily for erosive esophagitis and miss a dose, take it as soon as you remember if it's within 12 hours of the missed dose. If more than 12 hours have passed, skip the missed dose and take your next dose at the regularly scheduled time. Never double-up the dose to make up for the missed dose.

          • If you're taking Voquezna (vonoprazan) twice daily for H.pylori infection and miss a dose, take it as soon as you remember if it's within 4 hours of the missed dose. If more than 4 hours have passed, skip the missed dose and take your next dose at the regularly scheduled time.

            faqs

            Frequently asked questions about Voquezna (vonoprazan)

            How long does Voquezna (vonoprazan) take to work?
            It takes about 2 to 3 hours for Voquezna (vonoprazan) to lower the amount of acid in your stomach. The effects of Voquezna (vonoprazan) tend to last all day.
            Is Voquezna (vonoprazan) available in the United States?
            Yes, Voquezna (vonoprazan) is approved by the FDA and available in the US. But because it was approved fairly recently, not all pharmacies have it in stock. It's best to call your local pharmacy and ask if they have or can help you order Voquezna (vonoprazan).
            Is Voquezna (vonoprazan) FDA-approved?
            Yes, the FDA approved Voquezna (vonoprazan) in November 2023 for the treatment heartburn relief from erosive esophagitis and treatment of H. pylori. In July 2024, Voquezna (vonoprazan) received FDA-approval to help with heartburn from non-erosive GERD.
            Is Voquezna (vonoprazan) an antibiotic?
            No, Voquezna (vonoprazan) isn't an antibiotic; it's a potassium-competitive acid blocker (PCAB) that lowers the amount of acid in your stomach. But sometimes providers prescribe Voquezna (vonoprazan) with certain antibiotics (e.g., amoxicillin, clarithromycin) to treat a stomach infection caused by the bacteria H. pylori. The combination treatment also comes as easy-to-use dosing packs (e.g., Voquezna Dual Pak, Voquezna Triple Pak).
            How do you take Voquezna (vonoprazan)?
            Voquezna (vonoprazan) is taken by mouth with or without food. But if it's hurting your stomach, taking it with food could help. Swallow Voquezna (vonoprazan) tablets whole; don't chew or crush the tablet.
            Who should not take Voquezna (vonoprazan)?
            Voquezna (vonoprazan) might not be appropriate for everyone. For example, it should be avoided by people who previously had an allergic reaction to it. It also must be avoided by people who are taking an antiviral medication called rilpivirine (Edurant) that needs stomach acid to become activated and work. Ask your provider if you're not sure whether Voquezna (vonoprazan) is a good option for you.
            GoodRxEducationalIcon

            How to save using GoodRx

            Compare Prices
            1. Compare PricesSpecify your dosage and quantity to find out exactly how much you can save.
            Select your free coupon
            2. Select your free couponYou can use the displayed coupon, or compare prices at other pharmacies near you.
            Show coupon to your pharmacist
            3. Show coupon to your pharmacistPresent your printed or electronic coupon when you pick up your prescription.
            Get free couponLearn more
            warings-icon

            What are the risks and warnings for Voquezna (vonoprazan)?

            Voquezna (vonoprazan) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

            risk-warning

            Possible risk of cancer

            In some rare cases, heartburn can be warning signs of a more serious stomach problem or cancer. Sometimes, taking heartburn medications, like Voquezna (vonoprazan), can mask these warning signs. If your heartburn symptoms don't go away after you've completed treatment with Voquezna (vonoprazan), contact your provider. You might need to undergo testing to see if you have a more serious problem like stomach cancer.

            risk-warning

            Kidney problems

            Some people reported inflammation in the kidneys after starting Voquezna (vonoprazan). Let your provider know if you notice changes to how much or how often you urinate, if you have blood in your urine, or are feeling unwell.

            risk-warning

            Infectious diarrhea

            Risk factor: Taking Voquezna (vonoprazan) for a long time | Recent or current hospital stays | Taking antibiotics at the same time

            Voquezna (vonoprazan) might raise your risk of infectious diarrhea from a bacteria called Clostridioides difficile (C. diff), which can be serious. It's important to recognize the difference between diarrhea as a side effect of Voquezna (vonoprazan) and this type of infectious diarrhea. Let your provider know if you experience diarrhea that doesn't get better over time, or is accompanied by fever, stomach cramps, and tiredness.

            risk-warning

            Weakened bones

            • Risk factors: Taking Voquezna (vonoprazan) for a long time

              Voquezna (vonoprazan) might weaken your bones and raise your risk of getting bone fractures. Your risk might be higher if you take Voquezna (vonoprazan) for a long time. Use Voquezna (vonoprazan) at the lowest dose and for the shortest amount of time possible for your condition.

              risk-warning

              Severe skin reactions

              Some people have reported severe skin reactions, such as Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), after starting Voquezna (vonoprazan). These reactions can be life-threatening, but occur very rarely with Voquezna (vonoprazan). If you experience flu-like symptoms or a painful rash, get medical help as soon as possible.

              risk-warning

              Low magnesium and vitamin B12 levels

              • Risk factors: Taking Voquezna (vonoprazan) for a long time | Taking other medications that lower vitamin B12 or magnesium

                Taking Voquezna (vonoprazan) for a long time can cause low vitamin B12 levels. Your risk is higher if you're taking other medications that can do the same, such as metformin (Glucophage). Let your provider know if you feel symptoms of low vitamin B12 include low energy, headaches, and tiredness.

                Voquezna (vonoprazan) can also lower magnesium levels, especially if you're taking other medication that can do the same, such as water pills or digoxin (Lanoxin). Talk to your provider if you notice any signs or symptoms of low magnesium (e.g., weakness or fatigue, muscle cramps, numbness).

                risk-warning

                Risk of false positive in lab test

                Let your provider know you're taking Voquezna (vonoprazan) before you receive lab tests that tests for neuroendocrine tumors. This medication can cause a rise in serum chromogranin A (CgA) level, which suggests you have a certain type of tumor when you don't. If you need to take a test for CgA level, you must wait at least 2 weeks after you're finished with Voquezna (vonoprazan) treatment.

                dosage

                Voquezna (vonoprazan) dosage forms

                The average cost for 30 tablets of 20mg of Voquezna (vonoprazan) is $25.00 with a free GoodRx coupon. This is 96.94% off the average retail price of $817.50.
                tablet
                Tablet
                DosageQuantityPrice as low asPrice per unit
                10mg30 tablets$25.00$0.83
                20mg30 tablets$25.00$0.83

                Typical dosing for Voquezna (vonoprazan)

                • Healing of erosive esophagitis and heartburn relief: The typical dose is 20 mg by mouth once per day for 2 months.

                • Maintenance of healed erosive esophagitis: The typical dose is 10 mg by mouth once a day for 6 months.

                • Heartburn relief from non-erosive GERD: The typical dose is 10 mg by mouth once a day for 4 weeks.

                • Treatment of H. pylori (used with antibiotics): The typical dose is 20 mg by mouth twice a day in combination with antibiotics for 14 days.

                Your dose will differ if you have kidney or liver problems.

                drug-cost

                How much does Voquezna (vonoprazan) cost?

                To access savings, use a GoodRx coupon and pay just a fraction of the retail price.View prices & coupons
                contraindications-icon

                Voquezna (vonoprazan) contraindications

                Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Voquezna (vonoprazan) will not be safe for you to take.

                Taking rilpivirine (Edurant)

                alternatives

                What are alternatives to Voquezna (vonoprazan)?

                There are a number of medications that your doctor can prescribe in place of Voquezna (vonoprazan). Compare a few possible alternatives below.
                Voquezna (vonoprazan)
                Used for:
                $25.00 Lowest GoodRx priceView Prices
                Used for:
                • Prevention and treatment of heartburn (gastroesophageal reflux disease or GERD)

                $6.60 Lowest GoodRx priceView Prices
                Used for:
                • Gastroesophageal reflux disease (GERD)

                • Inflamed esophagus due to GERD

                $5.88 Lowest GoodRx priceView Prices
                images

                Voquezna (vonoprazan) images

                Red Oval V20 - VOQUEZNA 20mg Tablet
                This medicine is Red, Oval Tablet Imprinted With "V20".Red Oval V20 - VOQUEZNA 20mg Tablet

                Get savings updates for Voquezna (vonoprazan)

                Receive price alerts, news, and other messages from GoodRx about Voquezna (vonoprazan) and other healthcare topics and relevant savings offers.

                By signing up, I agree to GoodRx's Terms and Privacy Policy, and to receive marketing messages from GoodRx.

                References

                Best studies we found

                Aggarwal, N., et al. (2023). S1905: Vonoprazan may increase the risk of fractures. American Journal of Gastroenterology.

                Brooks, A. (2024). Vonoprazan (Voquezna) Receives FDA Approval for Heartburn Associated with Non-Erosive GERD. HCP Live.

                Grossi, G., et al. (2023). FDA approves erosive GERD therapy Vonoprazan. American Journal of Managed Care.

                View All References (4)

                Neuroendocrine Tumor Research Foundation. (n.d.). Blood tests for neuroendocrine tumors.

                O’Brien, F., et al. (2023). Tubulointerstitial nephritis. Merck Manual Consumer Version.

                Phathom Pharmaceuticals. (n.d.). Voquezna works differently.

                Phathom Pharmaceuticals Inc. (2023). Voquezna- vonoprazan fumarate tablet [package insert]. DailyMed.

                GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
                Was this page helpful?

                Browse medications

                View All

                Research prescriptions and over-the-counter medications from A to Z, compare drug prices, and start saving.