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Voquezna Dual Pak Coupon - Voquezna Dual Pak 20mg/500mg carton

Voquezna Dual Pak

vonoprazan / amoxicillin
Used for Bacterial Infection
Used for Bacterial Infection

Voquezna Dual Pak (vonoprazan / amoxicillin) is used to treat Helicobacter pylori (H. pylori) infections in adults. It's made up of 2 separate medications packaged together in a blister pack. Vonoprazan is a potassium-competitive acid blocker (PCAB) that's taken by mouth twice a day to lower stomach acid. Amoxicillin is a penicillin antibiotic that's taken by mouth three time a day to fight the infection. The entire treatment lasts 2 weeks. Some common side effects of Voquezna Dual Pak (vonoprazan / amoxicillin) include diarrhea and stomach pain.

Reviewed by:
reviewer
Robert Chad Hakim, PharmD, BCCCP
reviewer
Kristianne Hannemann, PharmD
Last reviewed on January 22, 2024
BasicsSide effectsPros & consPharmacist tipsFAQsWarningsDosageCostContraindicationsAlternativesImagesReferencesPricesMedicare
basics-icon

What is Voquezna Dual Pak (vonoprazan / amoxicillin)?

What is Voquezna Dual Pak (vonoprazan / amoxicillin) used for?

How Voquezna Dual Pak (vonoprazan / amoxicillin) works

Voquezna Dual Pak (vonoprazan / amoxicillin) is a combination of two medications that treat stomach infections caused by the bacteria Helicobacter pylori (H. pylori):

  • Vonoprazan is a potassium-competitive acid blocker (PCAB). It blocks a protein to stop stomach acid from being made and released into your stomach. This prevents stomach acid from irritating your stomach.

  • Amoxicillin is a penicillin antibiotic. It kills bacteria by preventing them from making their own protective covering in your body.

Are you looking for information on Voquezna (vonoprazan) or Voquezna Triple Pak (vonoprazan / amoxicillin / clarithromycin) instead?

Drug Facts

Common BrandsVoquezna Dual Pak
Drug ClassPCAB / Penicillin antibiotic
Controlled Substance ClassificationNot a controlled medication
Generic StatusNo lower-cost generic available
AvailabilityPrescription only
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$1004.73(save 16.87%)
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$835.20
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What are the side effects of Voquezna Dual Pak (vonoprazan / amoxicillin)?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Diarrhea (5%)
  • Stomach pain (3%)
  • Vaginal yeast infection (2%)
  • Sore throat and runny nose (2%)

Other Side Effects

  • Headache
  • Changes in taste or metallic taste

Serious Side Effects

Contact your healthcare provider immediately if you experience any of the following.
  • Serious allergic reaction: difficulty breathing, hives, itching, fast heartbeat, tightness in the throat, nausea, stomach pain, dizziness, lightheadedness, swelling in the face or tongue
  • Severe skin reaction: red or purple skin rash, blisters on skin, peeling skin, fever
  • Infectious diarrhea: loose and watery stools, severe stomach pain or cramps, fever, nausea

Source: DailyMed

The following side effects have also been reported

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
  • Rash, fever, and swollen lymph nodes
  • Redness, blistering, peeling, or loosening of the skin, including inside the mouth
  • Severe diarrhea, fever
  • Severe or prolonged vomiting or diarrhea
  • Unusual vaginal discharge, itching, or odor

Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):

pros-and-cons

Pros and cons of Voquezna Dual Pak (vonoprazan / amoxicillin)

thumbs-up

Pros

Works well to treat H. pylori infections, including infections caused by certain resistant (hard-to-treat) bacteria

Conveniently packaged as 2-week treatment packs

Can be taken with or without food

thumbs-down

Cons

Taken three times a day

Can't be used in people with serious kidney or liver problems

No generics available

pharmacist-tips

Pharmacist tips for Voquezna Dual Pak (vonoprazan / amoxicillin)

pharmacist

  • Take Voquezna Dual Pak (vonoprazan / amoxicillin) with or without food. Since antibiotics can typically cause stomach side effects (e.g., nausea, stomach upset, diarrhea), you can try taking your pills with food to help.

    • Avoid drinking alcohol while taking Voquezna Dual Pak (vonoprazan / amoxicillin). Doing so can worsen stomach side effects, like nausea and stomach upset.

      • Contact your provider you develop severe diarrhea with symptoms such as stomach cramps, fever, and tiredness. This might be a symptom of infectious diarrhea – a rare, but serious side effect of Voquezna Dual Pak (vonoprazan / amoxicillin) that needs immediate medical attention.

        • Make sure to finish all of the medication in the 2-week course, even if you start to feel better before then. This is to make sure Voquezna Dual Pak (vonoprazan / amoxicillin) gets rid of the infection so you don't get sick again. Stopping treatment earlier than prescribed can make your infection come back and become resistant (harder to treat).

          • Voquezna Dual Pak (vonoprazan / amoxicillin) interacts with many medications. For example, because vonoprazan makes your stomach less acidic, it can affect how well your body absorbs certain antiviral medications. Tell your provider about all of the medications you're taking before starting Voquezna Dual Pak (vonoprazan / amoxicillin).

            • If you miss your dose of Voquezna Dual Pak (vonoprazan / amoxicillin), take it as soon as you remember if it's within 4 hours of the missed dose. If more than 4 hours has passed, skip the dose and continue the next dose at the regularly scheduled time. Never double-up the dose to make up for the missed dose.

              faqs

              Frequently asked questions about Voquezna Dual Pak (vonoprazan / amoxicillin)

              Is Voquezna Dual Pak (vonoprazan / amoxicillin) an antibiotic?
              Yes. Voquezna Dual Pak contains amoxicillin, which is an antibiotic used to kill the H. pylori bacteria.
              Is Voquezna Dual Pak (vonoprazan / amoxicillin) FDA-approved?
              Yes, the FDA approved Voquezna Dual Pak (vonoprazan / amoxicillin) in May of 2022 for the treatment of H. pylori infection in adults.
              How long does Voquezna Dual Pak (vonoprazan / amoxicillin) take to work?
              Voquezna Dual Pak (vonoprazan / amoxicillin) starts to work soon after your first dose. Vonoprazan begins to lower the amount of acid in your stomach 2 to 3 hours after you take it. Amoxicillin starts to fight off the bacteria in your stomach quickly, but it can take 2 to 3 days before you start to feel better. Regardless of how quickly your condition improve after starting Voquezna Dual Pak (vonoprazan / amoxicillin), it's important you finish the entire prescribed treatment course. Stopping the medication too early can make your infection come back and become harder to treat.
              How well does Voquezna Dual Pak (vonoprazan / amoxicillin) work?
              In clinical studies, Voquezna Dual Pak (vonoprazan / amoxicillin) worked just as well to treat H.pylori infection compared to people who used standard therapy with lansoprazole / clarithromycin / amoxicillin (former brand name Prevpac). Also, Voquezna Dual Pak (vonoprazan / amoxicillin) worked even better to treat people with a resistant (difficult-to-treat bacteria) strain of H. pylori compared to people taking Prevpac.
              Can you drink while taking Voquezna Dual Pak (vonoprazan / amoxicillin)?
              Don't drink alcohol while taking Voquezna Dual Pak (vonoprazan / amoxicillin). In general, you should avoid drinking alcohol while taking antibiotics because doing so can worsen stomach-related side effects, such as nausea, vomiting, diarrhea. In addition, drinking alcohol can make it more difficult to heal from your infection.
              Can you take Voquezna Dual Pak (vonoprazan / amoxicillin) while pregnant?
              If you're pregnant and diagnosed with a H. pylori infection, discuss with your provider about possible treatment options. Voquezna Dual Pak (vonoprazan / amoxicillin) hasn't been well-studied in pregnancy. While amoxicillin is considered safe for people who are pregnant, there's not much information about how vonoprazan might affect pregnancy. Based on limited animal studies, there's a chance that vonoprazan might harm developing babies.
              Is Voquezna Dual Pak (vonoprazan / amoxicillin) safe if I'm breastfeeding?
              Probably not. Animal studies show that vonoprazan can pass into breast milk, but it's unclear how this might affect a nursing baby. To be safe, don't breastfeed while taking and for 2 days after completing Voquezna Dual Pak (vonoprazan / amoxicillin). In the meantime, consider feeding your baby previously stored breast milk or formula. If you’re breastfeeding, talk to your provider about the risks and benefits of taking Voquezna Dual Pak (vonoprazan / amoxicillin).
              What's the difference between Voquezna Dual Pak and Voquezna Triple Pak?
              The main difference between them is that Voquezna Triple Pak contains one additional antibiotic, clarithromycin. Another difference is that Voquezna Dual Pak is taken by mouth 3 times daily, whereas Voquezna Triple Pak is taken twice daily. Your provider will determine which medication is appropriate for your infection.
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              What are the risks and warnings for Voquezna Dual Pak (vonoprazan / amoxicillin)?

              Voquezna Dual Pak (vonoprazan / amoxicillin) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

              risk-warning

              Severe allergic reactions

              Severe allergic reactions to Voquezna Dual Pak (vonoprazan / amoxicillin) are possible, including life-threatening reactions like facial swelling, hives, and anaphylaxis (e.g., closing of the throat).

              Voquezna Dual Pak (vonoprazan / amoxicillin) can also cause serious skin reactions, such as Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). These reactions typically start off as aching, headaches, fever, or a burning sensation in the eyes. You could also get blisters, redness, or a red or purple rash on your skin. If you notice any signs of a severe allergic or skin reaction after taking Voquezna Dual Pak (vonoprazan / amoxicillin), get medical attention right away.

              risk-warning

              Infectious diarrhea

              Voquezna Dual Pak (vonoprazan / amoxicillin) can put you at a higher risk for getting Clostridioides difficile (C. difficile)-associated diarrhea (CDAD), a dangerous side effect. Like many other bacteria, C. difficile naturally lives in your gut and normally don’t cause any problems. But taking antibiotics, like amoxicillin, can cause C. difficile to grow out of control. This can lead to infectious diarrhea which can cause rapid heart rate, foul-smelling diarrhea, fever, nausea, frequent bowel movements (even up to 15 times per day) and is an emergency. If you have any of these symptoms, get medical attention right away so your provider can test you for infectious diarrhea. Your provider might ask you to stop Voquezna Dual Pak (vonoprazan / amoxicillin).

              risk-warning

              Risk of false positive in lab test

              Let your provider know you're taking Voquezna Dual Pak (vonoprazan / amoxicillin) before you receive lab tests that tests for neuroendocrine tumors. This medication can cause a rise in serum chromogranin A (CgA) level, which suggests you have a certain type of tumor when you don't. If you need to take a test for CgA level, you must wait at least 2 weeks after you're finished with Voquezna Dual Pak (vonoprazan / amoxicillin) treatment.

              risk-warning

              Difficult-to-treat infections

              Only take Voquezna Dual Pak (vonoprazan / amoxicillin) if your provider confirmed you have H. pylori stomach infection and prescribed this medication for you. Don't share this medication with anyone else. Taking Voquezna Dual Pak (vonoprazan / amoxicillin) when it's not needed can raise the risk of developing infections that can be more difficult to treat in the future.

              dosage

              Voquezna Dual Pak (vonoprazan / amoxicillin) dosage forms

              The average cost for 1 carton of 20mg/500mg of Voquezna Dual Pak (vonoprazan / amoxicillin) is $835.20 with a free GoodRx coupon. This is 16.87% off the average retail price of $1004.73.
              carton
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              DosageQuantityPrice as low asPrice per unit
              20mg/500mg1 carton$835.20$835.20

              Typical dosing for Voquezna Dual Pak (vonoprazan / amoxicillin)

              Each pack contains vonoprazan 20 mg tablets and amoxicillin 500 mg capsules.

              The typical dose is 1 tablet of vonoprazan by mouth two times a day (morning and evening) and 2 capsules of amoxicillin by mouth three times a day for a total of 14 days.

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              How much does Voquezna Dual Pak (vonoprazan / amoxicillin) cost?

              To access savings, use a GoodRx coupon and pay just a fraction of the retail price.
              Voquezna Dual Pak (brand)
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              contraindications-icon

              Voquezna Dual Pak (vonoprazan / amoxicillin) contraindications

              Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Voquezna Dual Pak (vonoprazan / amoxicillin) will not be safe for you to take.

              • Severe allergy to vonoprazan or amoxicillin (or other penicillin antibiotic)

              • Taking a product with rilpivirine (Edurant)

              alternatives

              What are alternatives to Voquezna Dual Pak (vonoprazan / amoxicillin)?

              There are a number of medications that your doctor can prescribe in place of Voquezna Dual Pak (vonoprazan / amoxicillin). Compare a few possible alternatives below.
              Voquezna Dual Pak (vonoprazan / amoxicillin)
              Used for:
              $835.20 Lowest GoodRx priceView Prices
              Omeclamox-Pak
              Used for:
              $508.10 Lowest GoodRx priceView Prices
              Voquezna Triple Pak
              Used for:
              $833.30 Lowest GoodRx priceView Prices
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              Voquezna Dual Pak (vonoprazan / amoxicillin) images

              Yellow Amox 500 Gg849 - VOQUEZNA Dual Pak
              This medicine is Yellow Carton Imprinted With "Amox 500 Gg849".Yellow Amox 500 Gg849 - VOQUEZNA Dual Pak

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              References

              Best studies we found

              Chey, W. D., et al. (2022). Vonoprazan triple and dual therapy for Helicobacter pylori infection in the United States and Europe: Randomized clinical trial. Gastroenterology.

              Neuroendocrine Tumor Research Foundation. (n.d.). Blood tests for neuroendocrine tumors.

              Phathom Pharmaceuticals. (n.d.). Voquezna works differently.

              View All References (2)

              Phathom Pharmaceuticals Inc. (2024). Voquezna Dual Pak- vonoprazan fumarate and amoxicillin kit; Voquezna Triple Pak- vonoprazan fumarate, amoxicillin and clarithromycin kit [package insert]. DailyMed.

              U.S. Food and Drug Administration. (2023). Drug Trials Snapshots: Voquezna Triple Pak, Voquezna Dual Pak.

              GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
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