Medications for diabetic neuropathy help relieve nerve pain caused by diabetes. Some of these medications also have other uses, such as managing chronic pain or treating fibromyalgia. They work in various ways to change the way your brain and nerves process pain signals. Common classes include serotonin and norepinephrine reuptake inhibitors (SNRIs) and anti-epileptics. SNRIs like duloxetine (Cymbalta, Drizalma Sprinkle) are usually taken as oral pills. Anti-epileptics, such as pregabalin (Lyrica, Lyrica CR), also come in oral forms. These options provide different ways to help manage your nerve pain effectively.