Local anesthetic / serotonin norepinephrine reuptake inhibitor (SNRI) kits are used to manage chronic pain. The local anesthetic temporarily relieves pain by blocking pain signals in your nerves. The SNRI treats long-term pain by increasing the levels of serotonin and norepinephrine in your brain, which helps reduce pain. Examples of local anesthetic / SNRI kits include Duloxicaine, which contains the local anesthetic lidocaine as a topical cream and the SNRI duloxetine as oral capsules. You can use the medications in the kit to reduce pain.