Duloxicaine

Duloxetine in the Duloxicaine (duloxetine / lidocaine) kit can raise the risk of suicidal thoughts or behavior. The risk is higher in young adults or people who've had depression. Watch for new or worsening depression, thoughts of harming yourself, or unusual behavior, especially during the first few months of taking duloxetine or when your dose changes. Let your healthcare provider know right away if you notice any unusual changes in mood or behavior, such as feeling more anxious, irritable, or having trouble sleeping, while taking duloxetine. Your provider will discuss with you about what next steps to take.

Sometimes, depression is the first symptom of bipolar disorder. Treating someone with bipolar disorder with duloxetine (which can also be used as an antidepressant) alone can cause a manic episode (great excitement, delusions, and overactivity). This is more likely to happen if you or someone in your family has had bipolar disorder. Talk to your provider right away if you notice unusual changes in your behavior after taking duloxetine from the Duloxicaine (duloxetine / lidocaine) kit.

Although rare, some people taking duloxetine capsules have had serious and sometimes life-threatening liver problems. If you develop any stomach pain, swelling in your legs, changes in the color of your stool, nausea, vomiting, or yellowing of the whites of your eyes (jaundice), tell your provider right away. You might need to stop taking the duloxetine capsules to prevent further liver injury.

Serotonin syndrome is a rare, but potentially life-threatening condition where there is an excess of serotonin in the brain. Serotonin is one of the chemicals in your brain responsible for your mood. Your risk for this condition goes up if you take the duloxetine capsules in the Duloxicaine (duloxetine / lidocaine) kit with other medications that affect serotonin levels, such as dextromethorphan (Delsym), tramadol (Ultram), and MAOIs. Make sure your provider knows about all the medications (including over-the-counter medications and supplements) you take or plan to take before you start using the Duloxicaine (duloxetine / lidocaine) kit so they can make sure they're safe for you. Get medical help as soon as possible if you have symptoms of serotonin syndrome, such as fast heart rate, sweating, muscle stiffness or spasms, high fever, and confusion.

The duloxetine capsules in the Duloxicaine (duloxetine / lidocaine) kit can cause changes to your blood pressure (both up or down). For example, the medication can cause a sudden drop in blood pressure when you stand up from a sitting or lying down position. This can make you feel dizzy and put you at higher risk for falls. This type of blood pressure change tends to start within the first week of treatment, but can occur at any time, particularly after your duloxetine dose gets raised. Get up very slowly when you're changing positions, such as getting up after lying down. Also make sure to check your blood pressure regularly during treatment with Duloxicaine (duloxetine / lidocaine).

The duloxetine capsules in the Duloxicaine (duloxetine / lidocaine) kit can raise the risk of bleeding or bruising. This risk is higher you're also taking aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), or blood thinners. The bleeding can range from nosebleeds to stomach bleeds and at times can be life-threatening. Tell your healthcare provider about any bruising that doesn't go away, black-colored stools, pink or red urine, or unusual bleeding from the nose or gums.

In clinical studies, some males who took duloxetine capsules had sexual problems, such as low sex drive and erectile dysfunction. Some females might experience low sex drive with duloxetine use as well. If you notice any bothersome sexual problems while taking Duloxicaine (duloxetine / lidocaine), contact your provider.

The lidocaine cream in the Duloxicaine (duloxetine / lidocaine) kit can cause a rare but serious medical condition called methemoglobinemia. This condition prevents your red blood cells from bringing enough oxygen to your body. You can develop methemoglobinemia even if you’re using lidocaine at the recommended dose. If you have a risk factor for the condition (e.g., heart or lung problem, genetic problem called G6PD deficiency), please talk with your provider before using the lidocaine cream. Get medical attention right away if you notice signs and symptoms of methemoglobinemia, such as gray- or blue-colored skin, headache, fast heart beat, shortness of breath, dizziness, and lack of energy.