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Regranex Coupon - Regranex 15g of 0.01% tube of gel

Regranex

becaplermin
Used for Diabetic Neuropathy
Used for Diabetic Neuropathy

Regranex (becaplermin) is a platelet-derived growth factor. It's a topical gel that's FDA-approved to treat diabetes sores (ulcers) in the legs or feet of people ages 16 years and older who still have good blood supply to these regions. Regranex (becaplermin) works best if it's used along with good ulcer and wound care. This medication is applied once daily to the ulcers, then rinsed off after 12 hours. Typically, treatment continues until the ulcers are completely healed. The most common side effect is red rashes. Regranex (becaplermin) must be stored in the refrigerator when not in use.

Last reviewed on July 23, 2024
basics-icon

What is Regranex (becaplermin)?

What is Regranex (becaplermin) used for?

How Regranex (becaplermin) works

Regranex (becaplermin) is a platelet-derived growth factor. When you put it on sores and ulcers, it helps repair damaged skin. It helps to speed up the wound healing process by gathering your healing cells together in order to repair the open wound (ulcer).

Drug Facts

Common BrandsRegranex
Drug ClassTopical skin product
Controlled Substance ClassificationNot a controlled medication
Generic StatusNo lower-cost generic available
AvailabilityPrescription only
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$1684.52(save 19.86%)
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$1349.94
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What are the side effects of Regranex (becaplermin)?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Red skin rash (2%)

Other Side Effects

  • Burning sensation at the site of application

Serious Side Effects

Contact your healthcare provider immediately if you experience any of the following.
  • Abnormal skin growth

Source: DailyMed

The following side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Less common

Rash or redness of the skin near the skin ulcer

Incidence not known

Burning sensation at the application site

unusually warm skin

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

pros-and-cons

Pros and cons of Regranex (becaplermin)

thumbs-up

Pros

Can help heal ulcers

Might start to see improvements to ulcers within 2 weeks

Applied once daily

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Cons

Needs to be refrigerated

Can cause some burning or redness at the application site

Might raise the risk for cancer

pharmacist-tips

Pharmacist tips for Regranex (becaplermin)

pharmacist
  • Only use the amount of Regranex (becaplermin) as instructed by your prescriber. They'll check the size of your ulcer every 1-2 weeks and might change the dose depending on the size.

    • If you haven't noticed an improvement in your ulcer after using Regranex (becaplermin) for 2.5 months or complete healing after treatment for 4 months, let your diabetes care team know. They might need to talk with you about other treatment options.

      • Don't use Regranex (becaplermin) near your mouth, eyes, or vagina. It's meant to be used only on sores (ulcers) on your legs or feet.

        • You should store Regranex (becaplermin) in a refrigerator and take it out only when you're ready to apply it. Don't use it after the expiration date.

          • Regranex (becaplermin) works best in healing diabetes leg and foot ulcers when used along with proper wound and ulcer care. It's important to take the pressure off your ulcers as it's healing and change your wound dressings as directed by your care team.

            • After your ulcers have healed with the help of Regranex (becaplermin), it's important to continue to protect your feet so that new ulcers are less likely to open up. Check your feet daily to look for cuts, wear well-fitting close-toed shoes in the house and outside to prevent injuries, and exercise regularly to improve blood flow throughout your body.

              How to apply Regranex (becaplermin):

              • Wash your hands before and after treatment with Regranex (becaplermin).

                • Carefully measure the amount of Regranex (becaplermin) your prescriber told you and squeeze your dose onto a clean, firm, non-absorbent surface (such as wax paper).

                  • Use a cotton swab or another clean tool to help you apply a thin layer of Regranex (becaplermin) to your ulcer. Don't let the tip of the medication tube touch your wound. If you get Regranex (becaplermin) on any other area of skin, rinse it off with water.

                    • Cover the area with a gauze dressing moistened with saline after applying Regranex (becaplermin).

                      • After 12 hours, remove Regranex (becaplermin) by taking off the gauze dressing and rinsing the ulcer with saline or water. Cover the ulcer with a new moistened dressing (no medication) for the rest of the day.

                        faqs

                        Frequently asked questions about Regranex (becaplermin)

                        How well does Regranex (becaplermin) work?
                        When Regranex (becaplermin) was used together with good ulcer care in a clinical study that lasted 4 months, 50% of people treated with Regranex (becaplermin) had complete ulcer closure at the end of the study. This was compared to 35% of people who used a placebo gel (no active medication). Keep in mind that each person will experience different results based on things like the size of the ulcer and other health conditions. Talk with your diabetes care team if you've more questions about how well Regranex (becaplermin) works.
                        How long can Regranex (becaplermin) be out of the refrigerator?
                        There isn't enough information to know how long Regranex (becaplermin) can be kept outside of the refrigerator. To be safe, only take the medication out of the refrigerator when you're ready to use it and put it back as soon as you're done. Keep Regranex (becaplermin) in the refrigerator at 36°F to 46°F, and don't freeze it. If you've left the medication out of the refrigerator for a long period of time, let your diabetes care team know and they can talk with you about what to do next.
                        How long does it take for Regranex (becaplermin) to work?
                        Research shows that some people experienced complete healing of their ulcer within the first 2 weeks of using Regranex (becaplermin). But for most people, it takes months of daily use to see similar results. Typically, your diabetes care team will instruct you to use Regranex (becaplermin) daily until the diabetes ulcers have healed completely. Keep your follow-up appointments so they can check the progress of your healing. If you don't notice the ulcers shrinking one-third in size after 2.5 months of treatment or if you don't see complete healing after 4 months of treatment, let your care team know. They can let you know whether to continue Regranex (becaplermin) or talk with you about other treatment options.
                        What's the difference between Regranex (becaplermin) and Santyl?
                        Regranex (becaplermin) and Santyl (collagenase) are two products used on the skin to promote wound healing and growth of healthy skin. The main difference between the two is that Regranex (becaplermin) is specifically FDA-approved for treating diabetes ulcers on the legs or feet, whereas Santyl (collagenase) is used to remove damaged or burned skin as well as to treat many types of skin ulcers. Your prescriber might recommend using one or both of these medications for your ulcer.
                        What alternatives are there for Regranex (becaplermin)?
                        Currently, there aren't medications available that work the same way as Regranex (becaplermin) for diabetes foot or leg ulcers. Guidelines show that treatment can differ depending on the stage of the ulcer, but the goal is for the ulcer to close. In general, the standard treatment for diabetes foot or leg ulcers is proper wound care, which includes taking pressure off the ulcer, removing dead skin around the ulcer, and keeping the wound clean. Talk with your diabetes care team if you've more questions about how to take care of diabetes ulcers.
                        Can you use Regranex (becaplermin) for bed sores or other pressure ulcers?
                        Regranex (becaplermin) isn't FDA-approved for use on bed sores or other pressure ulcers. Regranex (becaplermin) was studied in people with venous leg ulcers, but results showed that it didn't work any better than placebo. Only use Regranex (becaplermin) as instructed by your healthcare professional.
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                        What are the risks and warnings for Regranex (becaplermin)?

                        Regranex (becaplermin) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

                        risk-warning

                        Risk of cancer

                        • Risk factors: Cancer at application site | History of cancer

                          Though rare, using Regranex (becaplermin) might raise the risk of cancers. Because this medication promotes the growth of new cells and blood vessels, there's a possibility that it can encourage the growth of cancer cells. Based on reports, people who developed cancer after starting Regranex (becaplermin) had cancer in locations different from where they applied the medication. Before starting Regranex (becaplermin), let your diabetes care team know if you have had or currently have cancer. They can discuss with you the benefits and possible harms of using Regranex (becaplermin) to help you decide whether you want to start treatment.

                          risk-warning

                          Application site reactions

                          Regranex (becaplermin) can cause irritation and rashes around the treated area. Talk to your diabetes care team if it becomes unbearable for you.

                          dosage

                          Regranex (becaplermin) dosage forms

                          The average cost for 1 tube of 15g of 0.01% of Regranex (becaplermin) is $1349.94 with a free GoodRx coupon. This is 19.86% off the average retail price of $1684.52.
                          tube of gel
                          Tube of gel
                          DosageQuantityPrice as low asPrice per unit
                          15g of 0.01%1 tube$1349.94$1349.94

                          Typical dosing for Regranex (becaplermin)

                          • Adults and children ages 16 years and older: The amount of medication needed depends on the size of your ulcer. But generally, you apply a thin layer of gel once a day with a cotton swab. After that, cover the treated area with gauze moistened with saline, then leave it on for 12 hours. After 12 hours have passed, remove the gauze and rinse the treated area with water to remove the gel, and cover the area again with clean gauze moistened with saline. Repeat treatment daily.

                          Your diabetes care team will give you more specific directions.

                          interactions

                          Interactions between Regranex (becaplermin) and other drugs

                          Regranex (becaplermin) may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Regranex (becaplermin). Please note that only the generic name of each medication is listed below.

                          Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

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                          How much does Regranex (becaplermin) cost?

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                          Regranex (becaplermin) contraindications

                          Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Regranex (becaplermin) will not be safe for you to take.
                          • Abnormal growth at site of application

                          alternatives

                          What are alternatives to Regranex (becaplermin)?

                          There are a number of medications that your doctor can prescribe in place of Regranex (becaplermin). Compare a few possible alternatives below.
                          Regranex (becaplermin)
                          $1349.94 Lowest GoodRx priceView Prices
                          Used for:
                          • Removal of damaged or burned skin

                          $333.12 Lowest GoodRx priceView Prices
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                          Regranex (becaplermin) images

                          yellow - REGRANEX 0.01% Topical Gel
                          This medicine is Yellow Tube Of Gel.yellow - REGRANEX 0.01% Topical Gel

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                          References

                          Best studies we found

                          Frykberg, R. G., et al. (2002). Diabetic foot ulcers: Pathogenesis and management. American Family Physician.

                          Heldin, C. H., et al. (1999). Mechanism of action and in vivo role of platelet-derived growth factor. Physiological Reviews.

                          National Cancer Institute. (n.d.). Platelet-derived growth factor.

                          View All References (3)

                          Robles-Tenorio, A., et al. (2022). Venous leg ulcer. StatPearls.

                          Smith & Nephew, Inc. (2019). Collagenase santyl ointment [package insert]. DailyMed.

                          Smith & Nephew, Inc. (2023). Regranex- becaplermin gel [package insert]. DailyMed.

                          GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
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