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Santyl Coupon - Santyl 30g of 250 units/g tube of ointment

Santyl

collagenase
Used for Wound Care
Used for Wound Care

Santyl (collagenase) is a topical enzyme medication used to remove damaged or burned skin, aiding in wound care and the growth of healthy skin. This ointment is approved for use in adults and typically needs to be applied to the skin just once per day. Side effects aren't common, but you might notice some skin redness on areas surrounding your wound. Santyl (collagenase) is currently only available as a brand-name medication.

Reviewed by:
reviewer
Robert Chad Hakim, PharmD, BCCCP
reviewer
Allison Gourley, PharmD
Last reviewed on September 4, 2024
BasicsSide effectsPros & consPharmacist tipsFAQsWarningsDosageCostAlternativesImagesReferencesPricesMedicare
basics-icon

What is Santyl (collagenase)?

What is Santyl (collagenase) used for?

  • Removal of damaged or burned skin

How Santyl (collagenase) works

Santyl (collagenase) is an enzyme (protein) that breaks down collagen in damaged or dead skin. This allows for new, healthy skin to grow in its place to help wounds heal.

Drug Facts

Common BrandsSantyl
Drug ClassEnzyme
Controlled Substance ClassificationNot a controlled medication
Generic StatusNo lower-cost generic available
AvailabilityPrescription only
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Avg retail price
$371.95(save 16.38%)
GoodRx discount
$311.02
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What are the side effects of Santyl (collagenase)?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

See Risks and Warnings

Other Side Effects

  • Skin redness around the affected area

Source: DailyMed

The following side effects have also been reported

Side effects that you should report to your care team as soon as possible:

Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):

  • Mild skin irritation, redness, or dryness
pros-and-cons

Pros and cons of Santyl (collagenase)

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Pros

Applied directly on the affected area of skin

Typically used once per day

Not many side effects

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Cons

Only available as a brand-name medication

Healthy skin that comes into contact with the medication might turn red

Not known if safe in children younger than 18 years old

pharmacist-tips

Pharmacist tips for Santyl (collagenase)

pharmacist

  • Before applying Santyl (collagenase), make sure to clean your wound with a cleansing agent like a normal saline solution.

    • Apply Santyl (collagenase) directly to the affected area, or you can apply it to a sterile gauze pad first and then place it on the affected area.

      • If you have a skin infection and need to also use a topical antibiotic powder, apply the topical antibiotic to the infected area first, then apply Santyl (collagenase). If the infection doesn't improve, let your prescriber know because you might need to stop using Santyl (collagenase) until the infection clears.

        • Some people might experience some redness in healthy skin that comes into contact with Santyl (collagenase), so be careful to apply the ointment only to the affected area(s).

          • Store Santyl (collagenase) at room temperature only. Don't put it in the refrigerator or freezer.

            faqs

            Frequently asked questions about Santyl (collagenase)

            When do you stop using Santyl (collagenase) on wounds?
            There isn't a specific amount of time you'll need to use Santyl (collagenase). Your prescriber will usually stop treatment once your skin wound has healed, all unhealthy tissue has been removed, and new, healthy skin has grown in its place.
            Is there a generic for Santyl (collagenase) available?
            Currently, there's no lower-cost generic available for Santyl (collagenase). There is, however, a copay assistance program available. You can also check out GoodRx coupons to help lessen the cost.
            How long does it take for Santyl (collagenase) to work?
            In a clinical study, half of the people using collagenase ointments like Santyl (collagenase) saw their wounds heal within 6 weeks. This is compared to half of the people using placebo that saw their wounds heal within 8 weeks. But the time it takes for Santyl (collagenase) to work depends on your wound and how quickly your body heals. Check in with your healthcare professional regularly so they can monitor your progress.
            Should I still use Santyl (collagenase) if my skin becomes infected?
            It's usually okay to continue using Santyl (collagenase) if your skin becomes infected. If you notice signs of a skin infection like redness, itching, swelling, or pus, contact your prescriber. They might recommend a topical antibiotic powder. Apply the antibiotic first, then Santyl (collagenase). If the infection doesn't improve, let your prescriber know because you might need to stop using Santyl (collagenase) until the infection clears.
            Can I use Santyl (collagenase) for wrinkles?
            No. Though anti-wrinkle medications like tretinoin (Renova) work to lessen fine wrinkles by stimulating collagen production, Santyl (collagenase) breaks down collagen in damaged skin to help wound healing. Ask your prescriber for an anti-wrinkle medication that's appropriate for you.
            Does Santyl (collagenase) expire?
            Yes, Santyl (collagenase) expires. Don't use this medication beyond its expiration date because it might not work to heal your wounds. If your tube has expired, as your prescriber for a new prescription.
            Is Santyl (collagenase) safe for children?
            It's not known if Santyl (collagenase) is safe or works well in children younger than 18 years old. This is because it hasn't been studied in them. Ask your child's pediatrician for other available options.
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            What are the risks and warnings for Santyl (collagenase)?

            Santyl (collagenase) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

            risk-warning

            Caution with using other topical products

            • Risk factors: Products with mercury or silver | Products that affect your skin's properties

              Certain topical products can interact with Santyl (collagenase), which can affect how well it works. Avoid antiseptics with mercury or silver (e.g., SSD (silver sulfadiazine)) and acidic products. If you use these, make sure to clean the affected area repeatedly with normal saline before using Santyl (collagenase). Don't use other topical products on the affected area while using Santyl (collagenase) without talking to your prescriber or pharmacist.

              dosage

              Santyl (collagenase) dosage forms

              The average cost for 1 tube of 30g of 250 units/g of Santyl (collagenase) is $311.02 with a free GoodRx coupon. This is 16.38% off the average retail price of $371.95.
              tube of ointment
              Tube of ointment
              DosageQuantityPrice as low asPrice per unit
              30g of 250 units/g1 tube$311.02$311.02
              90g of 250 units/g1 tube$875.24$875.24

              Typical dosing for Santyl (collagenase)

              Santyl (collagenase) is typically applied directly on the affected area once per day. If instructed by your prescriber, you might need to apply it more often if the dressing over the affected area becomes dirty.

              drug-cost

              How much does Santyl (collagenase) cost?

              To access savings, use a GoodRx coupon and pay just a fraction of the retail price.
              Santyl (brand)
              GoodRx lowest price

              $311.02

              (save 16.38%)
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              alternatives

              What are alternatives to Santyl (collagenase)?

              There are a number of medications that your doctor can prescribe in place of Santyl (collagenase). Compare a few possible alternatives below.
              Santyl (collagenase)
              Used for:

              • Removal of damaged or burned skin

              $311.02 Lowest GoodRx priceView Prices
              Iodosorb (cadexomer iodine)
              Used for:

              • Skin wounds or ulcers

              View Prices
              images

              Santyl (collagenase) images

              This medicine is Colorless Tube Of Ointment.

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              References

              Best studies we found

              McCallon, S. K., et al. (2015). Optimizing wound bed preparation with collagenase enzymatic debridement. The Journal of the American College of Clinical Wound Specialists.

              Nemours KidsHealth. (2023). What is collagen?

              Smith & Nephew, Inc. (2019). Collagenase santyl ointment [package insert]. DailyMed.

              View All References (1)

              Smith-Nephew. (n.d.). Savings and reimbursement.

              GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
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