Key takeaways
Diphenhydramine (Benadryl) and acetaminophen/dextromethorphan/doxylamine (Vicks Nyquil Cold and Flu) are both over-the-counter medications used to treat symptoms related to allergies, colds, and flu. They both contain an antihistamine, which helps relieve symptoms like sneezing and runny nose. However, they differ in several ways. Diphenhydramine is a single-ingredient antihistamine, while Nyquil Cold and Flu is a combination medication that contains an analgesic (acetaminophen) and a cough suppressant (dextromethorphan) along with the antihistamine doxylamine. Diphenhydramine is available in various forms, such as tablets and liquid, and is used for allergies, cold symptoms, and as an occasional sleep aid. Nyquil Cold and Flu is available as capsules and liquid, specifically targeting cold and flu symptoms like cough, sore throat, and fever. Diphenhydramine can cause drowsiness and is not recommended for long-term use, especially in older adults, due to risks like memory problems. Nyquil Cold and Flu can also cause sleepiness and should not be taken with other medications containing acetaminophen, to avoid getting too much acetaminophen. Both medications may not be a good choice if you have other medical conditions. Talk to your pharmaicst or prescriber before taking to be sure the medication is right for you.
