ZzzQuil (diphenhydramine) is an antihistamine used as an over-the-counter sleep aid. Antihistamines often cause drowsiness and sedation and can be used to help with difficult falling asleep. ZzzQuil includes only the sleep-aid active ingredient from NyQuil, without the other ingredients to treat cough and cold symptoms. Diphenhydramine is also available as a generic, and under other brand names including Benadryl and Unisom.

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