Key takeaways
Olanzapine (Zyprexa) and aripiprazole lauroxil (Aristada) are both atypical antipsychotics, but they have some key differences. Olanzapine is available in both oral and injectable forms and is used to treat schizophrenia, bipolar disorder, and certain types of depression when combined with fluoxetine (Prozac). In contrast, aripiprazole lauroxil is only available as a long-acting injection and is used solely for treating schizophrenia. Olanzapine can be taken daily, while aripiprazole lauroxil is administered every 1 to 2 months by a healthcare provider. Olanzapine is available as a lower-cost generic, whereas aripiprazole lauroxil is only available as a brand medication, making it more expensive. Both medications can cause weight gain and high blood sugar, but olanzapine is more likely to cause sleepiness and anticholinergic side effects like dry mouth and constipation. Aripiprazole lauroxil has fewer side effects compared to some other antipsychotics but can cause injection site pain and is not recommended during pregnancy or breastfeeding.
