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Zoloft vs. Celexa

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Sertraline (Zoloft) and citalopram (Celexa) are both selective serotonin reuptake inhibitors (SSRIs) used to treat mental health conditions, but they have some differences. Sertraline (Zoloft) is used for a wider range of conditions, including depression, OCD, panic disorder, PTSD, PMDD, and social anxiety disorder, while citalopram (Celexa) is primarily used for depression. Both medications are taken once daily and can cause side effects like nausea and sleep problems. However, sertraline (Zoloft) is available in both tablet and liquid forms, whereas citalopram (Celexa) comes in tablet, capsule, and mint-flavored liquid forms. Sertraline (Zoloft) is less likely to cause weight gain compared to some other SSRIs, while citalopram (Celexa) has a low risk for weight gain but can sometimes cause weight loss. Both medications can lead to withdrawal symptoms if stopped suddenly and have risks of serious side effects like serotonin syndrome and QT prolongation. Always consult your healthcare provider before making any changes to your medication.

Sertraline

(Zoloft)

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Citalopram

(Celexa)

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Summary for Zoloft

Prescription only

Sertraline (Zoloft) is a selective serotonin reuptake inhibitor (SSRI). It's used to treat different mental health conditions, including depression and certain types of anxiety disorder, such as panic disorder. It's typically taken by mouth once per day. This medication is available as both a tablet and liquid. Common side effects of sertraline (Zoloft) include nausea, diarrhea, and dry mouth. It's best to avoid alcohol while taking sertraline (Zoloft) because this combination can worsen side effects of sertraline (Zoloft).

Indications for Zoloft

Pros and Cons for Zoloft

Pros

Cons

  • Can take up to 2 months before you feel the full benefits
  • More likely to cause diarrhea compared to other SSRIs
  • Might make it more difficult for you to fall asleep
  • Can cause withdrawal symptoms if you suddenly stop taking it
  • The liquid form contains alcohol

Common Side Effects for Zoloft

  • Nausea (26%)
  • Diarrhea (20%)
  • Difficulty sleeping (20%)
  • Dry mouth (14%)
  • Sleepiness (12%)

Warnings for Zoloft

  • Worsening depression, suicidal thoughts, and unusual behavior
  • Serotonin syndrome
  • Risk of bleeding
  • Not for use alone in bipolar disorder
  • Glaucoma
  • Life-threatening abnormal heart rhythm (QT prolongation)
  • Low blood sodium levels

Summary for Celexa

Prescription only

Citalopram (Celexa) is a first-choice medication for treating depression in adults. This antidepressant belongs to the drug class called selective serotonin reuptake inhibitors (SSRIs). Citalopram (Celexa) is typically taken by mouth once daily. It typically takes a few weeks or longer of consistent treatment to notice an improvement to your mood. Common side effects include nausea and dry mouth. There's a low risk for weight gain, but suddenly stopping the medication can lead to withdrawal symptoms (e.g., upset stomach, trouble sleeping, anxiety).

Indications for Celexa

Pros and Cons for Celexa

Pros

Cons

  • Can take a couple months before you feel the full effects of this medication
  • Can interact with other medications, especially those affecting serotonin levels or heart rhythm
  • Can cause withdrawal symptoms if you suddenly stop taking it
  • Not FDA-approved for children

Common Side Effects for Celexa

  • Nausea (21%)
  • Dry mouth (20%)
  • Sleepiness (18%)
  • Trouble sleeping (15%)
  • Sweating (11%)
  • Tremor (8%)
  • Diarrhea (8%)
  • Ejaculation problems (6%)

Warnings for Celexa

  • Worsening depression, suicidal thoughts, and unusual behavior
  • Life-threatening abnormal heart rhythm (QT prolongation)
  • Serotonin syndrome
  • Withdrawal
  • Higher risk of bleeding
  • Not for use in bipolar disorder by itself
  • Glaucoma
  • Low sodium levels

Prices with our coupons for Zoloft vs. Celexa

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Sertraline30 tablets / 50mg
$9.26$33.64
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Citalopram30 tablets / 20mg
$9.00$9.00
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