Key takeaways
Ondansetron (Zofran) and granisetron (Kytril) are both antiemetic medications used to prevent nausea and vomiting caused by chemotherapy and radiation. Ondansetron is available in various forms, including tablets, orally disintegrating tablets (ODT), liquid, and injections, while granisetron is available as tablets and intravenous (IV) infusions. Ondansetron is typically taken multiple times a day, whereas granisetron is usually taken once or twice daily on treatment days. Ondansetron can be used in children, but granisetron tablets are not recommended for children. Both medications can cause headaches and have the potential to lead to serotonin syndrome and heart rhythm problems. Both medications are availible as generics, however, granisetron is noted to be more expensive than ondansetron.
