Key takeaways
Diclofenac (Voltaren) and piroxicam (Feldene) are both nonsteroidal anti-inflammatory drugs (NSAIDs) used to treat pain and inflammation, but they have some key differences. Diclofenac is available in various formulations, including tablets, capsules, and powder, and is used for a wider range of conditions such as osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, migraines, and menstrual cramps. Piroxicam, on the other hand, is typically taken as a capsule once daily and is mainly used for osteoarthritis and rheumatoid arthritis. Diclofenac can be taken multiple times a day depending on the formulation, while piroxicam is usually taken once daily. Both medications carry risks of serious side effects like heart attack, stroke, and stomach bleeding, and have additional warnings for liver damage and severe asthma attacks. Both medicatios are available as lower-cost generics. Lastly, diclofenac is not recommended for use in children younger than 12 years old, while piroxicam hasn't been studied in children at all.
