Key takeaways
Vivelle-Dot (estradiol patch) and Elestrin (estradiol gel) are both estrogen replacement therapies used to relieve menopausal symptoms like hot flashes and night sweats. They are in the same medication class and work by replacing estrogen in the body. However, they differ in their forms and dosing. Vivelle-Dot is a transdermal patch applied twice a week, while Elestrin is a topical gel applied once daily to the upper arm. Vivelle-Dot is available as a generic (Dotti), but Elestrin is only available as a brand-name medication. Common side effects of Vivelle-Dot include headaches and breast tenderness, while Elestrin may cause breast tenderness and abnormal vaginal bleeding. Both medications carry risks of serious side effects like blood clots and certain cancers, and they may require additional progestin therapy if you have a uterus. You should apply the Vivelle-Dot patch to your lower stomach or buttocks, avoiding the waistline to prevent the patch from falling off.
