Key takeaways
Nevirapine (Viramune) and etravirine (Intelence) are both medications used to treat HIV infections when taken in combination with other antiretrovirals. They both belong to the same drug class, non-nucleoside reverse transcriptase inhibitors (NNRTIs). However, they have several differences. Nevirapine is available in both immediate-release and extended-release forms, as well as an oral suspension, while etravirine is available as tablets that can be dissolved in liquid. Nevirapine is typically started at a lower dose to minimize the risk of rash, which is a common side effect, and then increased after two weeks. Etravirine is taken twice daily after meals, and it is often used for people who have developed resistance to other HIV medications. Nevirapine is available as a generic, making it a lower-cost option, whereas etravirine is available as both a brand-name and generic medication. Both medications can cause severe skin and liver reactions, but etravirine is more likely to cause changes in cholesterol and blood sugar levels. Additionally, both medications interact with many other drugs, so it's important to discuss all medications you are taking with your healthcare provider.
