Key takeaways
Vilazodone (Viibryd) and desvenlafaxine (Pristiq) are both medications used to treat depression in adults, but they belong to different drug classes and have distinct mechanisms of action. Vilazodone is a selective serotonin reuptake inhibitor (SSRI) and a serotonin (5HT1A) receptor partial agonist, while desvenlafaxine is a serotonin and norepinephrine reuptake inhibitor (SNRI). This means that vilazodone primarily affects serotonin levels, whereas desvenlafaxine influences both serotonin and norepinephrine levels in the brain. Vilazodone is taken once daily with food and is less likely to cause weight gain and sexual side effects compared to other antidepressants. On the other hand, desvenlafaxine can be taken with or without food and may raise blood pressure, making it less suitable for those with uncontrolled high blood pressure or heart problems. Both medications can cause withdrawal symptoms if stopped abruptly. Both medications are available in brand and generic versions.
