Key takeaways
Tramadol (Ultram) and hydrocodone/acetaminophen (Vicodin) are both opioid medications used to treat pain that isn't relieved by non-opioid medications. However, they differ in several ways. Tramadol is a Schedule IV controlled substance, while hydrocodone/acetaminophen is a Schedule II controlled substance, which means hydrocodone/acetaminophen has a higher potential for misuse and dependency. Tramadol is available in both an immediate-release form, usually taken every 4 to 6 hours, and an extended-release form taken once daily. Hydrocodone/acetaminophen is usually taken every 4 to 6 hours as needed. Both medications can cause nausea, constipation, and dizziness. Both medications can also cause serious side effects like dangerously slow breathing and withdrawal symptoms, especially if mixed with alcohol or some other medications like benzodiazepines. Tramadol can increase the risk of serotonin syndrome and seizures.
